Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met

D. Plaseska, F. Kutlar, J. B. Wilson, B. B. Webber, Y. T. Zeng, T. H.J. Huisman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalHemoglobin
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

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    Plaseska, D., Kutlar, F., Wilson, J. B., Webber, B. B., Zeng, Y. T., & Huisman, T. H. J. (1990). Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met. Hemoglobin, 14(2), 177-183. https://doi.org/10.3109/03630269009046959