Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution

Αgamma;2134(h12) val→met

D. Plaseska, Ferdane Kutlar, J. B. Wilson, B. B. Webber, Y. T. Zeng, T. H.J. Huisman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

During a survey of cord blood samples of healthy Chinese babies an Aγ variant was detected by its partial separation from normal Aγ in a high performance liquid chromatographic experiment. Structural analysis of the isolated Aγ chain identified a Val-Met substitution at position Aγ134; this substitution created a rather unique Met-Met sequence. The ratio of Aγ to Aγ was about 2 to 3; thus, Hb F with this variant Aγ chain appears to have approximately normal stability.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalHemoglobin
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1990

Fingerprint

methionylmethionine
Valine
Fetal Blood
Methionine
Substitution reactions
Structural analysis
Blood
Liquids
Experiments
Surveys and Questionnaires

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Plaseska, D., Kutlar, F., Wilson, J. B., Webber, B. B., Zeng, Y. T., & Huisman, T. H. J. (1990). Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met. Hemoglobin, 14(2), 177-183. https://doi.org/10.3109/03630269009046959

Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution : Αgamma;2134(h12) val→met. / Plaseska, D.; Kutlar, Ferdane; Wilson, J. B.; Webber, B. B.; Zeng, Y. T.; Huisman, T. H.J.

In: Hemoglobin, Vol. 14, No. 2, 01.01.1990, p. 177-183.

Research output: Contribution to journalArticle

Plaseska, D, Kutlar, F, Wilson, JB, Webber, BB, Zeng, YT & Huisman, THJ 1990, 'Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution: Αgamma;2134(h12) val→met', Hemoglobin, vol. 14, no. 2, pp. 177-183. https://doi.org/10.3109/03630269009046959
Plaseska, D. ; Kutlar, Ferdane ; Wilson, J. B. ; Webber, B. B. ; Zeng, Y. T. ; Huisman, T. H.J. / Hb f-jiangsu, the first γ chain variant with a valine -methionine substitution : Αgamma;2134(h12) val→met. In: Hemoglobin. 1990 ; Vol. 14, No. 2. pp. 177-183.
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