Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

T. Harano, K. Harano, K. Doi, S. Ueda, K. Imai, Y. Ohba, Ferdane Kutlar, T. H.J. Huisman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
Issue number2
StatePublished - 1990

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical


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