Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

T. Harano, K. Harano, K. Doi, S. Ueda, K. Imai, Y. Ohba, Ferdane Kutlar, T. H.J. Huisman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalHemoglobin
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1990

Fingerprint

Fetal Hemoglobin
Gene Order
Globins
High performance liquid chromatography
Reverse-Phase Chromatography
Fetal Blood
Structural analysis
Names
Blood
Substitution reactions
Genes
High Pressure Liquid Chromatography
Newborn Infant
hemoglobin F Onoda

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

Cite this

Harano, T., Harano, K., Doi, K., Ueda, S., Imai, K., Ohba, Y., ... Huisman, T. H. J. (1990). Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn. Hemoglobin, 14(2), 217-222. https://doi.org/10.3109/03630269009046964

Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn. / Harano, T.; Harano, K.; Doi, K.; Ueda, S.; Imai, K.; Ohba, Y.; Kutlar, Ferdane; Huisman, T. H.J.

In: Hemoglobin, Vol. 14, No. 2, 01.01.1990, p. 217-222.

Research output: Contribution to journalArticle

Harano, T, Harano, K, Doi, K, Ueda, S, Imai, K, Ohba, Y, Kutlar, F & Huisman, THJ 1990, 'Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn', Hemoglobin, vol. 14, no. 2, pp. 217-222. https://doi.org/10.3109/03630269009046964
Harano, T. ; Harano, K. ; Doi, K. ; Ueda, S. ; Imai, K. ; Ohba, Y. ; Kutlar, Ferdane ; Huisman, T. H.J. / Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn. In: Hemoglobin. 1990 ; Vol. 14, No. 2. pp. 217-222.
@article{9f198ce78b574904bed8dacc86187e39,
title = "Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn",
abstract = "During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36{\%}; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.",
author = "T. Harano and K. Harano and K. Doi and S. Ueda and K. Imai and Y. Ohba and Ferdane Kutlar and Huisman, {T. H.J.}",
year = "1990",
month = "1",
day = "1",
doi = "10.3109/03630269009046964",
language = "English (US)",
volume = "14",
pages = "217--222",
journal = "Hemoglobin",
issn = "0363-0269",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Hb f-onoda or α2gγ2146(HC3)histyr a newly discovered fetal hemoglobin variant in a japanese newborn

AU - Harano, T.

AU - Harano, K.

AU - Doi, K.

AU - Ueda, S.

AU - Imai, K.

AU - Ohba, Y.

AU - Kutlar, Ferdane

AU - Huisman, T. H.J.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

AB - During a study of possible abnormalities in γglobin gene arrangements in Japanese newborns (1) we discovered one baby (γ233) with an abnormal γ chain that was present for about 36%; this observation was made when the cord blood lysate was analyzed by reversed phase high performance liquid chromatography (HPLC) (2) (Fig. 1). Structural analysis showed that this abnormal T chain had a His+Tyr substitution at position Y146; the chain was of the Gγ type. We named it Hb F-Onoda [α2Gγ2l46(HC3)HisTyr] after the name of the city where the baby was born.

UR - http://www.scopus.com/inward/record.url?scp=0025180094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025180094&partnerID=8YFLogxK

U2 - 10.3109/03630269009046964

DO - 10.3109/03630269009046964

M3 - Article

C2 - 1703139

AN - SCOPUS:0025180094

VL - 14

SP - 217

EP - 222

JO - Hemoglobin

JF - Hemoglobin

SN - 0363-0269

IS - 2

ER -