HB f-xin-su or aγt73(e17)asp→his: A new slow-moving fetal hemoglobin variant

M. Ma; H. Hu; F. Kutlar; J. B. Wilson; T. H.J. Huismn

doi:10.3109/03630268708998007

HB f-xin-su or ^aγ^t73(e17)asp→his: A new slow-moving fetal hemoglobin variant

M. Ma, H. Hu, F. Kutlar, J. B. Wilson, T. H.J. Huismn

Pulmonary Disease

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Abstract

A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the ^Aγ^T-chain was also present, this baby has two types of abnormal γchain. The variant was named Hb F-Xin-Su.

Original language	English (US)
Pages (from-to)	473-479
Number of pages	7
Journal	Hemoglobin
Volume	11
Issue number	5
DOIs	https://doi.org/10.3109/03630268708998007
State	Published - 1987

ASJC Scopus subject areas

Hematology
Clinical Biochemistry
Genetics(clinical)
Biochemistry, medical

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title = "HB f-xin-su or aγt73(e17)asp→his: A new slow-moving fetal hemoglobin variant",

abstract = "A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the AγT-chain was also present, this baby has two types of abnormal γchain. The variant was named Hb F-Xin-Su.",

author = "M. Ma and H. Hu and F. Kutlar and Wilson, {J. B.} and Huismn, {T. H.J.}",

note = "Funding Information: We thank the nursing staff of the Beimen Hospital in Urumqi for collecting the cord blood samples. This study was i n part supported by USPHS Research Grant HLB-05168. This i s contribution 81034 from the Department of Cell and Molecular Biology at the Medical College o f Georgia i n Augusta, Georgia.",

year = "1987",

doi = "10.3109/03630268708998007",

language = "English (US)",

volume = "11",

pages = "473--479",

journal = "Hemoglobin",

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TY - JOUR

T1 - HB f-xin-su or aγt73(e17)asp→his

T2 - A new slow-moving fetal hemoglobin variant

AU - Ma, M.

AU - Hu, H.

AU - Kutlar, F.

AU - Wilson, J. B.

AU - Huismn, T. H.J.

N1 - Funding Information: We thank the nursing staff of the Beimen Hospital in Urumqi for collecting the cord blood samples. This study was i n part supported by USPHS Research Grant HLB-05168. This i s contribution 81034 from the Department of Cell and Molecular Biology at the Medical College o f Georgia i n Augusta, Georgia.

PY - 1987

Y1 - 1987

N2 - A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the AγT-chain was also present, this baby has two types of abnormal γchain. The variant was named Hb F-Xin-Su.

AB - A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the AγT-chain was also present, this baby has two types of abnormal γchain. The variant was named Hb F-Xin-Su.

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ER -

HB f-xin-su or ^aγ^t73(e17)asp→his: A new slow-moving fetal hemoglobin variant

Abstract

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