HB f-xin-su or aγt73(e17)asp→his

A new slow-moving fetal hemoglobin variant

M. Ma, H. Hu, Ferdane Kutlar, J. B. Wilson, T. H.J. Huismn

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A slow-moving y chain variant was discovered in the cord blood of an infant born to parents of the Han nationality from Jiangsu. The variant, which migrated electrophoretically at alkaline pH between Hb A and Hb D, was characterized by an Asp→His substitution at γ 73, while residues γ75 and γ136 were occupied by Ile and Ala, respectively. As the AγT-chain was also present, this baby has two types of abnormal γchain. The variant was named Hb F-Xin-Su.

Original languageEnglish (US)
Pages (from-to)473-479
Number of pages7
JournalHemoglobin
Volume11
Issue number5
DOIs
StatePublished - Jan 1 1987

Fingerprint

Fetal Hemoglobin
Fetal Blood
Ethnic Groups
Blood
Substitution reactions
Parents
hemoglobin D

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ma, M., Hu, H., Kutlar, F., Wilson, J. B., & Huismn, T. H. J. (1987). HB f-xin-su or aγt73(e17)asp→his: A new slow-moving fetal hemoglobin variant. Hemoglobin, 11(5), 473-479. https://doi.org/10.3109/03630268708998007

HB f-xin-su or aγt73(e17)asp→his : A new slow-moving fetal hemoglobin variant. / Ma, M.; Hu, H.; Kutlar, Ferdane; Wilson, J. B.; Huismn, T. H.J.

In: Hemoglobin, Vol. 11, No. 5, 01.01.1987, p. 473-479.

Research output: Contribution to journalArticle

Ma, M, Hu, H, Kutlar, F, Wilson, JB & Huismn, THJ 1987, 'HB f-xin-su or aγt73(e17)asp→his: A new slow-moving fetal hemoglobin variant', Hemoglobin, vol. 11, no. 5, pp. 473-479. https://doi.org/10.3109/03630268708998007
Ma, M. ; Hu, H. ; Kutlar, Ferdane ; Wilson, J. B. ; Huismn, T. H.J. / HB f-xin-su or aγt73(e17)asp→his : A new slow-moving fetal hemoglobin variant. In: Hemoglobin. 1987 ; Vol. 11, No. 5. pp. 473-479.
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