Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant

J. J. Malcorra-Azpiazu, H. I. Balda-Aguirre, J. C. Diaz-Chico, H. Hu, J. B. Wilson, B. B. Webber, Ferdane Kutlar, Abdullah Kutlar, T. H.J. Huisman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalHemoglobin
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1988

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High performance liquid chromatography
Electrophoresis
Spain
Hemoglobins
Substitution reactions
Reticulocytes
Reverse-Phase Chromatography
Heterozygote
Polyacrylamide Gel Electrophoresis
High Pressure Liquid Chromatography
polyacrylamide gels

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Malcorra-Azpiazu, J. J., Balda-Aguirre, H. I., Diaz-Chico, J. C., Hu, H., Wilson, J. B., Webber, B. B., ... Huisman, T. H. J. (1988). Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant. Hemoglobin, 12(2), 163-170. https://doi.org/10.3109/03630268808998022

Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant. / Malcorra-Azpiazu, J. J.; Balda-Aguirre, H. I.; Diaz-Chico, J. C.; Hu, H.; Wilson, J. B.; Webber, B. B.; Kutlar, Ferdane; Kutlar, Abdullah; Huisman, T. H.J.

In: Hemoglobin, Vol. 12, No. 2, 01.01.1988, p. 163-170.

Research output: Contribution to journalArticle

Malcorra-Azpiazu, JJ, Balda-Aguirre, HI, Diaz-Chico, JC, Hu, H, Wilson, JB, Webber, BB, Kutlar, F, Kutlar, A & Huisman, THJ 1988, 'Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant', Hemoglobin, vol. 12, no. 2, pp. 163-170. https://doi.org/10.3109/03630268808998022
Malcorra-Azpiazu JJ, Balda-Aguirre HI, Diaz-Chico JC, Hu H, Wilson JB, Webber BB et al. Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant. Hemoglobin. 1988 Jan 1;12(2):163-170. https://doi.org/10.3109/03630268808998022
Malcorra-Azpiazu, J. J. ; Balda-Aguirre, H. I. ; Diaz-Chico, J. C. ; Hu, H. ; Wilson, J. B. ; Webber, B. B. ; Kutlar, Ferdane ; Kutlar, Abdullah ; Huisman, T. H.J. / Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant. In: Hemoglobin. 1988 ; Vol. 12, No. 2. pp. 163-170.
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