Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant

J. J. Malcorra-Azpiazu, H. I. Balda-Aguirre, J. C. Diaz-Chico, H. Hu, J. B. Wilson, B. B. Webber, F. Kutlar, A. Kutlar, T. H.J. Huisman

Research output: Contribution to journalArticle

11 Scopus citations


A new hemoglobin variant with a Ser→Phe substitution at position β 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45% respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytes.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
Issue number2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

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    Malcorra-Azpiazu, J. J., Balda-Aguirre, H. I., Diaz-Chico, J. C., Hu, H., Wilson, J. B., Webber, B. B., Kutlar, F., Kutlar, A., & Huisman, T. H. J. (1988). Hb las palms or α2β249(cd8)ser→phe, a mildly unstable hemiglobin variant. Hemoglobin, 12(2), 163-170. https://doi.org/10.3109/03630268808998022