Hb Q‐Thailand‐Hb H disease in a chinese living in Geneva, Switzerland: Characterization of the variant and identification of the two α‐thalassemic chromosomes

P. Beris, P. Huber, P. A. Miescher, J. B. Wilson, A. Kutlar, S. S. Chen, T. H.J. Huisman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalAmerican Journal of Hematology
Volume24
Issue number4
DOIs
StatePublished - Apr 1987

Keywords

  • HPLC
  • gene mapping
  • α‐thal‐1
  • α‐thal‐2

ASJC Scopus subject areas

  • Hematology

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