Hb Q‐Thailand‐Hb H disease in a chinese living in Geneva, Switzerland: Characterization of the variant and identification of the two α‐thalassemic chromosomes

P. Beris, P. Huber, P. A. Miescher, J. B. Wilson, A. Kutlar, S. S. Chen, T. H.J. Huisman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalAmerican Journal of Hematology
Volume24
Issue number4
DOIs
StatePublished - Apr 1987

Fingerprint

Globins
Switzerland
Chromosomes
Chromosome Mapping
Liquid Chromatography
Genes
Hemoglobins

Keywords

  • HPLC
  • gene mapping
  • α‐thal‐1
  • α‐thal‐2

ASJC Scopus subject areas

  • Hematology

Cite this

Hb Q‐Thailand‐Hb H disease in a chinese living in Geneva, Switzerland : Characterization of the variant and identification of the two α‐thalassemic chromosomes. / Beris, P.; Huber, P.; Miescher, P. A.; Wilson, J. B.; Kutlar, A.; Chen, S. S.; Huisman, T. H.J.

In: American Journal of Hematology, Vol. 24, No. 4, 04.1987, p. 395-400.

Research output: Contribution to journalArticle

@article{cb2c133c729747bd8dd0ed27bc9a5655,
title = "Hb Q‐Thailand‐Hb H disease in a chinese living in Geneva, Switzerland: Characterization of the variant and identification of the two α‐thalassemic chromosomes",
abstract = "Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.",
keywords = "HPLC, gene mapping, α‐thal‐1, α‐thal‐2",
author = "P. Beris and P. Huber and Miescher, {P. A.} and Wilson, {J. B.} and A. Kutlar and Chen, {S. S.} and Huisman, {T. H.J.}",
year = "1987",
month = "4",
doi = "10.1002/ajh.2830240409",
language = "English (US)",
volume = "24",
pages = "395--400",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Hb Q‐Thailand‐Hb H disease in a chinese living in Geneva, Switzerland

T2 - Characterization of the variant and identification of the two α‐thalassemic chromosomes

AU - Beris, P.

AU - Huber, P.

AU - Miescher, P. A.

AU - Wilson, J. B.

AU - Kutlar, A.

AU - Chen, S. S.

AU - Huisman, T. H.J.

PY - 1987/4

Y1 - 1987/4

N2 - Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.

AB - Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.

KW - HPLC

KW - gene mapping

KW - α‐thal‐1

KW - α‐thal‐2

UR - http://www.scopus.com/inward/record.url?scp=0023175770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023175770&partnerID=8YFLogxK

U2 - 10.1002/ajh.2830240409

DO - 10.1002/ajh.2830240409

M3 - Article

C2 - 2882671

AN - SCOPUS:0023175770

VL - 24

SP - 395

EP - 400

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 4

ER -