Abstract
Data on a 24‐year‐old Chinese male with Hb Q‐Thailand‐Hb H disease are presented. The hemoglobin variant was characterized by fast microprocedures, mainly by reverse‐phase high‐performance liquid chromatography. Gene mapping analyses identified the α‐thalassemia‐2, which is associated with the α‐Q chain, as caused by a 4.2‐kb deletion involving the α2 globin gene, while the α‐thalassemia‐1 anomaly was the common Southeast Asian type in which part of the Ψζ, the Ψα, and the α2 and α1 globin genes are deleted.
Original language | English (US) |
---|---|
Pages (from-to) | 395-400 |
Number of pages | 6 |
Journal | American Journal of Hematology |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1987 |
Keywords
- HPLC
- gene mapping
- α‐thal‐1
- α‐thal‐2
ASJC Scopus subject areas
- Hematology