TY - JOUR
T1 - Hdac-mediated control of endochondral and intramembranous ossification
AU - Bradley, Elizabeth W.
AU - McGee-Lawrence, Meghan E.
AU - Westendorf, Jennifer J.
PY - 2011
Y1 - 2011
N2 - Histone deacetylases (Hdacs) remove acetyl groups (CH3CO-) from e-amino groups in lysine residues within histones and other proteins. This posttranslational (de) modification alters protein stability, protein-protein interactions, and chromatin structure. Hdac activity plays important roles in the development of all organs and tissues, including the mineralized skeleton. Bone is a dynamic tissue that forms and regenerates by two processes: endochondral and intramembranous ossification. Chondrocytes and osteoblasts are responsible for producing the extracellular matrices of skeletal tissues. Several Hdacs contribute to the molecular pathways and chromatin changes that regulate tissue-specific gene expression during chondrocyte and osteoblast specification, maturation, and terminal differentiation. In this review, we summarize the roles of class I and class II Hdacs in chondrocytes and osteoblasts. The effects of small molecule Hdac inhibitors on the skeleton are also discussed.
AB - Histone deacetylases (Hdacs) remove acetyl groups (CH3CO-) from e-amino groups in lysine residues within histones and other proteins. This posttranslational (de) modification alters protein stability, protein-protein interactions, and chromatin structure. Hdac activity plays important roles in the development of all organs and tissues, including the mineralized skeleton. Bone is a dynamic tissue that forms and regenerates by two processes: endochondral and intramembranous ossification. Chondrocytes and osteoblasts are responsible for producing the extracellular matrices of skeletal tissues. Several Hdacs contribute to the molecular pathways and chromatin changes that regulate tissue-specific gene expression during chondrocyte and osteoblast specification, maturation, and terminal differentiation. In this review, we summarize the roles of class I and class II Hdacs in chondrocytes and osteoblasts. The effects of small molecule Hdac inhibitors on the skeleton are also discussed.
KW - Cartilage
KW - Chondrocytes
KW - Lysine deacetylase
KW - Osteoblasts
KW - Runx2
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U2 - 10.1615/critreveukargeneexpr.v21.i2.10
DO - 10.1615/critreveukargeneexpr.v21.i2.10
M3 - Review article
C2 - 22077150
AN - SCOPUS:80755136753
SN - 1045-4403
VL - 21
SP - 101
EP - 113
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 2
ER -