Head and neck cancer: The importance of oxygen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: To use recently introduced polarographic technology to characterize the distribution of oxygenation in solid tumors, explore the differences between severe hypoxia and true necrosis, and evaluate the ability to predict treatment outcomes based on tumor oxygenation. Study Design: Prospective, nonrandomized trial of patients with advanced head and neck cancer, conducted at an academic institution. Methods: A total of 63 patients underwent polarographic oxygen measurements of their tumors. Experiment 1 was designed to determine whether gradient of oxygenation exists within tumors by examining several series of measurements in each tumor. Experiment 2 was an analysis of the difference in data variance incurred when comparing oxygen measurements using oxygen electrodes of two different sizes. Experiment 2 compared the proportion of tumor necrosis to the proportion of very low (≤2.5 mm Hg) polarographic oxygen measurements. Experiment 4 was designed to explore the correlation between oxygenation and treatment outcomes after nonsurgical management. Results: No gradient of oxygenation was found within cervical lymph node metastases from head and neck squamous cell carcinomas (P > .9). Tumor measurements achieved with larger (17 μm) electrodes displayed smaller variances than those obtained with smaller (12 μm) electrodes, although this difference failed to reach statistical significance (P = .60). There was no correlation between tumor necrosis and the proportion of very low (≤2.5 mm Hg) oxygen measurements. There was a nonsignificant trend toward poorer locoregional control and overall survival in hypoxic tumors. Conclusions: Hypoxia exists within cervical lymph node metastases from head and neck squamous carcinomas, but the hypoxic regions are distributed essentially randomly. As expected, measurements of oxygen achieved with larger electrodes results in lowered variance, but with no change in overall tumor mean oxygen levels. Polarographic oxygen measurements are independent of tumor necrosis. Finally, oxygenation as an independent variable is incapable of predicting prognosis, probably reflecting the multifactorial nature of the biological behavior of head and neck cancer.

Original languageEnglish (US)
Pages (from-to)697-707
Number of pages11
JournalLaryngoscope
Volume110
Issue number5 I
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Oxygen
Neoplasms
Electrodes
Necrosis
Lymph Nodes
Neoplasm Metastasis
Squamous Cell Carcinoma
Neck
Head
Prospective Studies
Technology
Survival

Keywords

  • Microelectrode
  • Necrosis
  • Oxygen tension
  • Tumor biology
  • Variance

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Head and neck cancer : The importance of oxygen. / Terris, David J.

In: Laryngoscope, Vol. 110, No. 5 I, 01.01.2000, p. 697-707.

Research output: Contribution to journalArticle

Terris, David J. / Head and neck cancer : The importance of oxygen. In: Laryngoscope. 2000 ; Vol. 110, No. 5 I. pp. 697-707.
@article{f52c7f62c3a34ce9a6f7f9f323b92042,
title = "Head and neck cancer: The importance of oxygen",
abstract = "Objectives: To use recently introduced polarographic technology to characterize the distribution of oxygenation in solid tumors, explore the differences between severe hypoxia and true necrosis, and evaluate the ability to predict treatment outcomes based on tumor oxygenation. Study Design: Prospective, nonrandomized trial of patients with advanced head and neck cancer, conducted at an academic institution. Methods: A total of 63 patients underwent polarographic oxygen measurements of their tumors. Experiment 1 was designed to determine whether gradient of oxygenation exists within tumors by examining several series of measurements in each tumor. Experiment 2 was an analysis of the difference in data variance incurred when comparing oxygen measurements using oxygen electrodes of two different sizes. Experiment 2 compared the proportion of tumor necrosis to the proportion of very low (≤2.5 mm Hg) polarographic oxygen measurements. Experiment 4 was designed to explore the correlation between oxygenation and treatment outcomes after nonsurgical management. Results: No gradient of oxygenation was found within cervical lymph node metastases from head and neck squamous cell carcinomas (P > .9). Tumor measurements achieved with larger (17 μm) electrodes displayed smaller variances than those obtained with smaller (12 μm) electrodes, although this difference failed to reach statistical significance (P = .60). There was no correlation between tumor necrosis and the proportion of very low (≤2.5 mm Hg) oxygen measurements. There was a nonsignificant trend toward poorer locoregional control and overall survival in hypoxic tumors. Conclusions: Hypoxia exists within cervical lymph node metastases from head and neck squamous carcinomas, but the hypoxic regions are distributed essentially randomly. As expected, measurements of oxygen achieved with larger electrodes results in lowered variance, but with no change in overall tumor mean oxygen levels. Polarographic oxygen measurements are independent of tumor necrosis. Finally, oxygenation as an independent variable is incapable of predicting prognosis, probably reflecting the multifactorial nature of the biological behavior of head and neck cancer.",
keywords = "Microelectrode, Necrosis, Oxygen tension, Tumor biology, Variance",
author = "Terris, {David J}",
year = "2000",
month = "1",
day = "1",
doi = "10.1097/00005537-200005000-00001",
language = "English (US)",
volume = "110",
pages = "697--707",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "Wiley-Blackwell",
number = "5 I",

}

TY - JOUR

T1 - Head and neck cancer

T2 - The importance of oxygen

AU - Terris, David J

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Objectives: To use recently introduced polarographic technology to characterize the distribution of oxygenation in solid tumors, explore the differences between severe hypoxia and true necrosis, and evaluate the ability to predict treatment outcomes based on tumor oxygenation. Study Design: Prospective, nonrandomized trial of patients with advanced head and neck cancer, conducted at an academic institution. Methods: A total of 63 patients underwent polarographic oxygen measurements of their tumors. Experiment 1 was designed to determine whether gradient of oxygenation exists within tumors by examining several series of measurements in each tumor. Experiment 2 was an analysis of the difference in data variance incurred when comparing oxygen measurements using oxygen electrodes of two different sizes. Experiment 2 compared the proportion of tumor necrosis to the proportion of very low (≤2.5 mm Hg) polarographic oxygen measurements. Experiment 4 was designed to explore the correlation between oxygenation and treatment outcomes after nonsurgical management. Results: No gradient of oxygenation was found within cervical lymph node metastases from head and neck squamous cell carcinomas (P > .9). Tumor measurements achieved with larger (17 μm) electrodes displayed smaller variances than those obtained with smaller (12 μm) electrodes, although this difference failed to reach statistical significance (P = .60). There was no correlation between tumor necrosis and the proportion of very low (≤2.5 mm Hg) oxygen measurements. There was a nonsignificant trend toward poorer locoregional control and overall survival in hypoxic tumors. Conclusions: Hypoxia exists within cervical lymph node metastases from head and neck squamous carcinomas, but the hypoxic regions are distributed essentially randomly. As expected, measurements of oxygen achieved with larger electrodes results in lowered variance, but with no change in overall tumor mean oxygen levels. Polarographic oxygen measurements are independent of tumor necrosis. Finally, oxygenation as an independent variable is incapable of predicting prognosis, probably reflecting the multifactorial nature of the biological behavior of head and neck cancer.

AB - Objectives: To use recently introduced polarographic technology to characterize the distribution of oxygenation in solid tumors, explore the differences between severe hypoxia and true necrosis, and evaluate the ability to predict treatment outcomes based on tumor oxygenation. Study Design: Prospective, nonrandomized trial of patients with advanced head and neck cancer, conducted at an academic institution. Methods: A total of 63 patients underwent polarographic oxygen measurements of their tumors. Experiment 1 was designed to determine whether gradient of oxygenation exists within tumors by examining several series of measurements in each tumor. Experiment 2 was an analysis of the difference in data variance incurred when comparing oxygen measurements using oxygen electrodes of two different sizes. Experiment 2 compared the proportion of tumor necrosis to the proportion of very low (≤2.5 mm Hg) polarographic oxygen measurements. Experiment 4 was designed to explore the correlation between oxygenation and treatment outcomes after nonsurgical management. Results: No gradient of oxygenation was found within cervical lymph node metastases from head and neck squamous cell carcinomas (P > .9). Tumor measurements achieved with larger (17 μm) electrodes displayed smaller variances than those obtained with smaller (12 μm) electrodes, although this difference failed to reach statistical significance (P = .60). There was no correlation between tumor necrosis and the proportion of very low (≤2.5 mm Hg) oxygen measurements. There was a nonsignificant trend toward poorer locoregional control and overall survival in hypoxic tumors. Conclusions: Hypoxia exists within cervical lymph node metastases from head and neck squamous carcinomas, but the hypoxic regions are distributed essentially randomly. As expected, measurements of oxygen achieved with larger electrodes results in lowered variance, but with no change in overall tumor mean oxygen levels. Polarographic oxygen measurements are independent of tumor necrosis. Finally, oxygenation as an independent variable is incapable of predicting prognosis, probably reflecting the multifactorial nature of the biological behavior of head and neck cancer.

KW - Microelectrode

KW - Necrosis

KW - Oxygen tension

KW - Tumor biology

KW - Variance

UR - http://www.scopus.com/inward/record.url?scp=0034020976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034020976&partnerID=8YFLogxK

U2 - 10.1097/00005537-200005000-00001

DO - 10.1097/00005537-200005000-00001

M3 - Article

C2 - 10807350

AN - SCOPUS:0034020976

VL - 110

SP - 697

EP - 707

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 5 I

ER -