Healthy aging and disease: Role for telomere biology?

Haidong Zhu, Matthew Belcher, Pim Van Der Harst

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer. Despite the remarkable progress made during the last two decades, our understanding of the biology of aging remains incomplete. Telomere biology has recently emerged as an important player in the aging and disease process.

Original languageEnglish (US)
Pages (from-to)427-440
Number of pages14
JournalClinical Science
Volume120
Issue number10
DOIs
StatePublished - May 1 2011

Keywords

  • Aging
  • Alzheimer's disease
  • Atherosclerosis
  • Heart failure
  • Longevity
  • Parkinson's disease
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Medicine(all)

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