Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation

Varsha Surendranath Taskar, J. John, E. Evander, P. Wollmer, B. Robertson, B. Jonson

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The possible occurrence of lung damage if alveolar units are allowed to collapse and reopen breath by breath during mechanical ventilation with normal tidal volumes was investigated. Anaesthetised, paralysed, open chest rabbits were subjected to either intrathoracic negative (NEEP; n=6) or positive (PEEP; n=6) end‐expiratory pressure during volume controlled mechanical ventilation. Both experimental settings were preceded by a 30 min control period and followed by a 30 min recovery period during which a PEEP of 0.2 kPa was maintained. Pao2 and pulmonary compliance deteriorated significantly in the NEEP group during the experimental period and compared to ventilation with PEEP. Partial restoration of lung mechanics and blood gases was achieved during the recovery period. After an alveolar recruitment manoeuvre, this recovery was complete. Lung clearance studied by depositing an aerosol of technetium‐99m‐labelled diethylenetriamine pentaacetate (99mTc‐DTPA) in the alveoli, was significantly faster during ventilation with NEEP compared to the PEEP group (P=0.0002) as well as the control period (P= 0.0029). It did not recover completely during the recovery period but remained significantly faster. light microscopic histology was normal in both groups with no evidence of inflammation or epithelial disruption. We conclude that previously healthy rabbit lungs show only a transient disturbance of lung mechanics and blood gases with repetitive collapse and re‐expansion. The integrity of the alveolar rnicrostructure is preserved. The disturbance in the alveolo‐capillary permeability persists and may indicate surfactant related alveolo‐capillary barrier dysfunction.

Original languageEnglish (US)
Pages (from-to)370-376
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Volume39
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Artificial Respiration
Lung
Mechanics
Ventilation
Gases
Rabbits
Lung Compliance
Tidal Volume
Aerosols
Surface-Active Agents
Permeability
Histology
Thorax
Inflammation
Light
Pressure

Keywords

  • Atelectasis
  • barotrauma
  • histology
  • lung collapse
  • lung physiology
  • permeability

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation. / Taskar, Varsha Surendranath; John, J.; Evander, E.; Wollmer, P.; Robertson, B.; Jonson, B.

In: Acta Anaesthesiologica Scandinavica, Vol. 39, No. 3, 01.01.1995, p. 370-376.

Research output: Contribution to journalArticle

Taskar, Varsha Surendranath ; John, J. ; Evander, E. ; Wollmer, P. ; Robertson, B. ; Jonson, B. / Healthy lungs tolerate repetitive collapse and reopening during short periods of mechanical ventilation. In: Acta Anaesthesiologica Scandinavica. 1995 ; Vol. 39, No. 3. pp. 370-376.
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