TY - JOUR
T1 - Hearing loss in children with asymptomatic congenital cytomegalovirus infection
AU - Congenital Cytomegalovirus Longitudinal Study Group
AU - Lanzieri, Tatiana M.
AU - Chung, Winnie
AU - Flores, Marily
AU - Blum, Peggy
AU - Caviness, A. Chantal
AU - Bialek, Stephanie R.
AU - Grosse, Scott D.
AU - Miller, Jerry A.
AU - Demmler-Harrison, Gail
AU - Ahmed, Shahzad
AU - Baer, Hanna
AU - Bhatt, Amit R.
AU - Brown, Frank
AU - Catlin, Francis
AU - Caviness, Alison C.
AU - Coats, David K.
AU - Edmonds, Jane C.
AU - Franklin, Daniel
AU - Gandaria, Cindy
AU - Greer, Jewel
AU - Griesser, Carol
AU - Hussein, Mohamed A.
AU - Iovino, Isabella
AU - Istas, Allison
AU - Jin, Haoxing
AU - Kelinske, Mary K.
AU - Klingen, Joseph T.
AU - Laurente, Antone
AU - Littman, Thomas
AU - Murphy, Mary
AU - Miller, Jerry
AU - Nelson, Christopher
AU - Noyola, Daniel
AU - Paysse, Evelyn A.
AU - Percy, Alan
AU - Reis, Sara
AU - Reynolds, Ann
AU - Rozelle, Judith
AU - Smith, O'Brien
AU - Steinkuller, Paul
AU - Turcich, Marie
AU - Vinson, Sherry Sellers
AU - Voigt, Robert G.
AU - Walmus, Bethann
AU - Williams, Jill
AU - Williamson, Daniel
AU - Yen, Kimberly G.
AU - Yow, Martha D.
AU - Demmler-Harrison, Gail J.
N1 - Funding Information:
This study was supported in part by the CMV Research Fund Donors at Baylor College of Medicine; the Woman's Hospital of Texas Research Foundation; the Office of Research Resources and the General Clinical Research Center for Children at Texas Children's Hospital and Baylor College of Medicine (NIH 5M0I RR00188-33); the Mental Retardation Research Center at Baylor College of Medicine (NIH-CHHD 5 P30 HD24064P); the Research to Prevent Blindness, Inc (New York, NY); the Deafness Foundation (Houston, TX); the Vale Ashe Foundation (Houston, TX); the Maddie's Mission Foundation (Katy, TX); the Naymola Foundation (Beaumont, TX); the American Pediatric Society-Society for Pediatric Research Summer Student Research Program (NIH-CHHD); and the Centers for Disease Control and Prevention (cooperative agreement FOA IP 10-006). Funded by the National Institutes of Health (NIH).
Publisher Copyright:
Copyright © 2017 by the American Academy of Pediatrics.
PY - 2017/3
Y1 - 2017/3
N2 - objectives: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospitalbased newborn screening who were asymptomatic at birth compared with uninfected children. METHODS: We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate the prevalence of SNHL, defined as ≥25 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups. RESULTS: At age 18 years, SNHL prevalence was 25% (95% confidence interval [CI]: 17%-36%) among case-patients and 8% (95% CI: 3%-22%) in controls (hazard ratio [HR]: 4.0; 95% CI: 1.2-14.5; P = .02). Among children without SNHL by age 5 years, the risk of delayedonset SNHL was not significantly greater for case-patients than for controls (HR: 1.6; 95% CI: 0.4-6.1; P = .5). Among case-patients, the risk of delayed-onset SNHL was significantly greater among those with unilateral congenital/early-onset hearing loss than those without (HR: 6.9; 95% CI: 2.5-19.1; P < .01). The prevalence of severe to profound bilateral SNHL among case-patients was 2% (95% CI: 1%-9%). CONCLUSIONS: Delayed-onset and progression of SNHL among children with asymptomatic congenital cytomegalovirus infection continued to occur throughout adolescence. However, the risk of developing SNHL after age 5 years among case-patients was not different than in uninfected children. Overall, 2% of case-patients developed SNHL that was severe enough for them to be candidates for cochlear implantation.
AB - objectives: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospitalbased newborn screening who were asymptomatic at birth compared with uninfected children. METHODS: We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate the prevalence of SNHL, defined as ≥25 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups. RESULTS: At age 18 years, SNHL prevalence was 25% (95% confidence interval [CI]: 17%-36%) among case-patients and 8% (95% CI: 3%-22%) in controls (hazard ratio [HR]: 4.0; 95% CI: 1.2-14.5; P = .02). Among children without SNHL by age 5 years, the risk of delayedonset SNHL was not significantly greater for case-patients than for controls (HR: 1.6; 95% CI: 0.4-6.1; P = .5). Among case-patients, the risk of delayed-onset SNHL was significantly greater among those with unilateral congenital/early-onset hearing loss than those without (HR: 6.9; 95% CI: 2.5-19.1; P < .01). The prevalence of severe to profound bilateral SNHL among case-patients was 2% (95% CI: 1%-9%). CONCLUSIONS: Delayed-onset and progression of SNHL among children with asymptomatic congenital cytomegalovirus infection continued to occur throughout adolescence. However, the risk of developing SNHL after age 5 years among case-patients was not different than in uninfected children. Overall, 2% of case-patients developed SNHL that was severe enough for them to be candidates for cochlear implantation.
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U2 - 10.1542/peds.2016-2610
DO - 10.1542/peds.2016-2610
M3 - Article
C2 - 28209771
AN - SCOPUS:85016019563
VL - 139
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 3
M1 - e20162610
ER -