Heart rate variability in left ventricular Hypertrophy

Mahendra K. Mandawat, David R. Wallbridge, Stuart D. Pringle, Abdulla A S Riyami, Shahid Latif, Peter W. MacFarlane, A. Ross Lorimer, Stuart M. Cobbe

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background-Electrocardiographic left ventricular hypertrophy and strain are associated with increased cardiac morbidity and mortality. Impaired cardiac autonomic function, assessed noninvasively by spontaneous heart rate variability on Holter monitoring, is associated with an increased risk of sudden death after myocardial infarction. Aim-To study the effect of left ventricular hypertrophy on heart rate variability. Patients-36 controls and 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease). Setting-Tertiary referral centre. Methods-Heart rate variability was measured on 24 h Holter recordings by non-spectral methods. Left ventricular mass index and fractional shortening were measured by echocardiography. Results-Patients with left ventricular hypertrophy had a higher left ventricular mass index (P < 0.001) and reduced heart rate variability (P< 0.001) compared with those of the controls. A continuous inverse relation was apparent between heart rate variability and left ventricular mass index (r = - 0.478, P < 0.001). Heart rate variability was not affected by age, the presence of coronary artery disease in patients with left ventricular hypertrophy, or β blocker treatment for hypertension. Multivariate analysis showed that left ventricular mass index is the most important determinant of heart rate variability. Conclusion-Heart rate variability is significantly reduced in patients with left ventricular hypertrophy secondary to hypertension or aortic valve disease. A continuous inverse relation exists between heart rate variability and left ventricular mass index. Impaired cardiac autonomic function in left ventricular hypertrophy may contribute to the mechanism of sudden death.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalHeart
Volume73
Issue number2
DOIs
StatePublished - Jan 1 1995

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Left Ventricular Hypertrophy
Heart Rate
Aortic Diseases
Sudden Death
Hypertension
Aortic Valve
Ambulatory Electrocardiography
Tertiary Care Centers
Echocardiography
Coronary Artery Disease
Multivariate Analysis
Myocardial Infarction
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mandawat, M. K., Wallbridge, D. R., Pringle, S. D., Riyami, A. A. S., Latif, S., MacFarlane, P. W., ... Cobbe, S. M. (1995). Heart rate variability in left ventricular Hypertrophy. Heart, 73(2), 139-144. https://doi.org/10.1136/hrt.73.2.139

Heart rate variability in left ventricular Hypertrophy. / Mandawat, Mahendra K.; Wallbridge, David R.; Pringle, Stuart D.; Riyami, Abdulla A S; Latif, Shahid; MacFarlane, Peter W.; Lorimer, A. Ross; Cobbe, Stuart M.

In: Heart, Vol. 73, No. 2, 01.01.1995, p. 139-144.

Research output: Contribution to journalArticle

Mandawat, MK, Wallbridge, DR, Pringle, SD, Riyami, AAS, Latif, S, MacFarlane, PW, Lorimer, AR & Cobbe, SM 1995, 'Heart rate variability in left ventricular Hypertrophy', Heart, vol. 73, no. 2, pp. 139-144. https://doi.org/10.1136/hrt.73.2.139
Mandawat MK, Wallbridge DR, Pringle SD, Riyami AAS, Latif S, MacFarlane PW et al. Heart rate variability in left ventricular Hypertrophy. Heart. 1995 Jan 1;73(2):139-144. https://doi.org/10.1136/hrt.73.2.139
Mandawat, Mahendra K. ; Wallbridge, David R. ; Pringle, Stuart D. ; Riyami, Abdulla A S ; Latif, Shahid ; MacFarlane, Peter W. ; Lorimer, A. Ross ; Cobbe, Stuart M. / Heart rate variability in left ventricular Hypertrophy. In: Heart. 1995 ; Vol. 73, No. 2. pp. 139-144.
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AU - MacFarlane, Peter W.

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