Abstract
Postpartem vasospasm in the umbilical arteries may be due to impaired vasorelaxation secondary to alterations in the expression of heat shock proteins. The contractile responses of pre- and full-term bovine umbilical artery smooth muscles were determined in a muscle bath. Heat shock protein expression was determined in bovine and human arterial tissues using western blotting with specific antisera. Full-term bovine and human umbilical artery smooth muscle was refractory to relaxation induced by the nitric oxide donor, sodium nitroprusside. This impaired vasorelaxation was associated with the expression of the inducible form of the heat shock protein, HSP70i, and increases in the expression of the small heat shock protein, HSP27. Small heat shock proteins have been implicated in modulating contraction and relaxation responses in vascular smooth muscles. Thus, alterations in heat shock protein expression may play a role in umbilical artery vasospasm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 351-355 |
| Number of pages | 5 |
| Journal | Journal of Reproduction and Fertility |
| Volume | 114 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1998 |
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ASJC Scopus subject areas
- Physiology
- Embryology
- Molecular Biology
- Obstetrics and Gynecology
- Developmental Biology
Cite this
Heat shock protein expression in umbilical artery smooth muscle. / Brophy, C. M.; Beall, A.; Mannes, K.; Lamb, S.; Dickinson, M.; Woodrum, D.; DeVoe, L. D.
In: Journal of Reproduction and Fertility, Vol. 114, No. 2, 11.1998, p. 351-355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heat shock protein expression in umbilical artery smooth muscle
AU - Brophy, C. M.
AU - Beall, A.
AU - Mannes, K.
AU - Lamb, S.
AU - Dickinson, M.
AU - Woodrum, D.
AU - DeVoe, L. D.
PY - 1998/11
Y1 - 1998/11
N2 - Postpartem vasospasm in the umbilical arteries may be due to impaired vasorelaxation secondary to alterations in the expression of heat shock proteins. The contractile responses of pre- and full-term bovine umbilical artery smooth muscles were determined in a muscle bath. Heat shock protein expression was determined in bovine and human arterial tissues using western blotting with specific antisera. Full-term bovine and human umbilical artery smooth muscle was refractory to relaxation induced by the nitric oxide donor, sodium nitroprusside. This impaired vasorelaxation was associated with the expression of the inducible form of the heat shock protein, HSP70i, and increases in the expression of the small heat shock protein, HSP27. Small heat shock proteins have been implicated in modulating contraction and relaxation responses in vascular smooth muscles. Thus, alterations in heat shock protein expression may play a role in umbilical artery vasospasm.
AB - Postpartem vasospasm in the umbilical arteries may be due to impaired vasorelaxation secondary to alterations in the expression of heat shock proteins. The contractile responses of pre- and full-term bovine umbilical artery smooth muscles were determined in a muscle bath. Heat shock protein expression was determined in bovine and human arterial tissues using western blotting with specific antisera. Full-term bovine and human umbilical artery smooth muscle was refractory to relaxation induced by the nitric oxide donor, sodium nitroprusside. This impaired vasorelaxation was associated with the expression of the inducible form of the heat shock protein, HSP70i, and increases in the expression of the small heat shock protein, HSP27. Small heat shock proteins have been implicated in modulating contraction and relaxation responses in vascular smooth muscles. Thus, alterations in heat shock protein expression may play a role in umbilical artery vasospasm.
UR - http://www.scopus.com/inward/record.url?scp=0032421196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032421196&partnerID=8YFLogxK
U2 - 10.1530/jrf.0.1140351
DO - 10.1530/jrf.0.1140351
M3 - Article
C2 - 10070365
AN - SCOPUS:0032421196
VL - 114
SP - 351
EP - 355
JO - Journal of Reproduction and Fertility
JF - Journal of Reproduction and Fertility
SN - 0022-4251
IS - 2
ER -