Hematopoiesis. Clinical application of colony-stimulating factors

John Edward Janik, Langdon L. Miller

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The deleterious effects of chemotherapy on normal hematopoietic tissues may produce severe or protracted deficiencies in red blood cells, neutrophils, or platelets, and result in life-threatening infection or bleeding. Hematopoietic growth factors have had a profound influence on the management of patients undergoing cancer chemotherapy. Three recombinant hematopoietic growth factors have been licensed for clinical use in the United States: erythropoietin, G-CSF, and GM-CSF. Erythropoietin reduces the transfusion requirements of chemotherapy-induced anemia, and G-CSF and GM-CSF prevent infections due to chemotherapy-induced neutropenia, shorten the duration of neutropenia following high-dose chemotherapy, and stem cell transplantation and mobilize stem cells for transplantation. This chapter reviews randomized placebo-controlled trials of the licensed colony-stimulating factors in management of patients with cancer and briefly examines new agents that stimulate megakaryocyte and platelet development.

Original languageEnglish (US)
Pages (from-to)157-189
Number of pages33
JournalGrowth Factors and Cytokines in Health and Disease
Volume3
Issue numberC
DOIs
StatePublished - Dec 1 1997

Fingerprint

Colony-Stimulating Factors
Chemotherapy
Hematopoiesis
Granulocyte-Macrophage Colony-Stimulating Factor
Drug Therapy
Stem Cell Transplantation
Granulocyte Colony-Stimulating Factor
Erythropoietin
Platelets
Neutropenia
Stem cells
Intercellular Signaling Peptides and Proteins
Blood Platelets
Megakaryocytes
Infection
Anemia
Neoplasms
Neutrophils
Blood
Randomized Controlled Trials

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Cancer Research

Cite this

Hematopoiesis. Clinical application of colony-stimulating factors. / Janik, John Edward; Miller, Langdon L.

In: Growth Factors and Cytokines in Health and Disease, Vol. 3, No. C, 01.12.1997, p. 157-189.

Research output: Contribution to journalReview article

Janik, John Edward ; Miller, Langdon L. / Hematopoiesis. Clinical application of colony-stimulating factors. In: Growth Factors and Cytokines in Health and Disease. 1997 ; Vol. 3, No. C. pp. 157-189.
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