Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family

Y. Kilinç, M. Kumi, A. Gurgey, C. Altay, B. B. Webber, J. B. Wilson, Abdullah Kutlar, T. H J Huisman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The testing program of cord blood samples for hemoglobin (Hb) abnormalities, presently conducted in a few centers of Turkish Universities, sometimes detects rare variants which may or may not affect the health of the newborn. One example to be described here is O-Padova which has been observed once before (1). The variant was detected in the blood of a newborn girl by starch gel electrophoresis at pH 9.0 (2); the mobility of the variant (presumably α2Xγ) was slightly slower than that of Hb C (or α2β26 Glu→Lys) (Fig. 1). Red cell lysates from the father and a 2-year-old brother contained a different Hb component with a mobility distinctly faster than that of Hb A2 or of Hb C; a minute quantity of a similar component (presumably α2 X 2) was also present in the cord blood red cell lysate of Baby E (Fig. 1). The baby was retested when 40 days old; her hematological values and those of her father and brother were normal (Table I). Quantitation by cation exchange high performance liquid chromatography (HPLC) (3) gave total Hb X values of 15.4% for the baby (Hb X + Hb Fx), 18.3% for the father (Hb X + Hb X2), and 12.8% for the brother (Hb X + Hb X2) (see also Table I).

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalHemoglobin
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1985

Fingerprint

Hemoglobins
Hemoglobin C
Fathers
Siblings
Blood
Fetal Blood
Hemoglobin A2
Cells
Starch Gel Electrophoresis
High performance liquid chromatography
Electrophoresis
Starch
Cations
Blood Cells
Gels
High Pressure Liquid Chromatography
Health
Newborn Infant
Testing

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

Cite this

Kilinç, Y., Kumi, M., Gurgey, A., Altay, C., Webber, B. B., Wilson, J. B., ... Huisman, T. H. J. (1985). Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family. Hemoglobin, 9(6), 621-625. https://doi.org/10.3109/03630268508997044

Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family. / Kilinç, Y.; Kumi, M.; Gurgey, A.; Altay, C.; Webber, B. B.; Wilson, J. B.; Kutlar, Abdullah; Huisman, T. H J.

In: Hemoglobin, Vol. 9, No. 6, 01.01.1985, p. 621-625.

Research output: Contribution to journalArticle

Kilinç, Y, Kumi, M, Gurgey, A, Altay, C, Webber, BB, Wilson, JB, Kutlar, A & Huisman, THJ 1985, 'Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family', Hemoglobin, vol. 9, no. 6, pp. 621-625. https://doi.org/10.3109/03630268508997044
Kilinç Y, Kumi M, Gurgey A, Altay C, Webber BB, Wilson JB et al. Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family. Hemoglobin. 1985 Jan 1;9(6):621-625. https://doi.org/10.3109/03630268508997044
Kilinç, Y. ; Kumi, M. ; Gurgey, A. ; Altay, C. ; Webber, B. B. ; Wilson, J. B. ; Kutlar, Abdullah ; Huisman, T. H J. / Hemoglobin o-padova or α230(b11)GLU→LYSβ2 observed in members of a turkish family. In: Hemoglobin. 1985 ; Vol. 9, No. 6. pp. 621-625.
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abstract = "The testing program of cord blood samples for hemoglobin (Hb) abnormalities, presently conducted in a few centers of Turkish Universities, sometimes detects rare variants which may or may not affect the health of the newborn. One example to be described here is O-Padova which has been observed once before (1). The variant was detected in the blood of a newborn girl by starch gel electrophoresis at pH 9.0 (2); the mobility of the variant (presumably α2Xγ) was slightly slower than that of Hb C (or α2β26 Glu→Lys) (Fig. 1). Red cell lysates from the father and a 2-year-old brother contained a different Hb component with a mobility distinctly faster than that of Hb A2 or of Hb C; a minute quantity of a similar component (presumably α2 X 2) was also present in the cord blood red cell lysate of Baby E (Fig. 1). The baby was retested when 40 days old; her hematological values and those of her father and brother were normal (Table I). Quantitation by cation exchange high performance liquid chromatography (HPLC) (3) gave total Hb X values of 15.4{\%} for the baby (Hb X + Hb Fx), 18.3{\%} for the father (Hb X + Hb X2), and 12.8{\%} for the brother (Hb X + Hb X2) (see also Table I).",
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