Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Agriculture & Biology

• apoptosis 54%
• constitutive photomorphogenesis 9 signalosome 99%
• cytokines 9%
• eukaryotic cells 8%
• gene targeting 10%
• hepatocytes 44%
• inclusion bodies 11%
• ligases 9%
• liver 35%
• mice 34%
• molecular weight 5%
• pro-apoptotic proteins 14%
• proteasome endopeptidase complex 69%
• protein degradation 10%
• proteins 13%
• proteolysis 9%
• receptors 6%
• ubiquitin 65%
• vertebrates 7%

Medicine & Life Sciences

• Apoptosis 36%
• Apoptosis Regulatory Proteins 11%
• COP9 Signalosome Complex 100%
• Cytokines 6%
• Eukaryota 10%
• Gene Knockout Techniques 12%
• Hepatocytes 41%
• Inclusion Bodies 11%
• Ligases 10%
• Liver 30%
• Molecular Weight 8%
• Proteasome Endopeptidase Complex 62%
• Proteins 10%
• Proteolysis 18%
• src Homology Domains 12%
• Ubiquitin 59%
• Ubiquitinated Proteins 14%
• Up-Regulation 7%
• Vertebrates 8%

Chemical Compounds

• Antiapoptotic 14%
• Protein 24%
• Protein Hydrolysis 10%
• Weight 5%