Hepatic epithelioid hemangioendothelioma in a patient with hemochromatosis

Nisar Ahmad, Denise M. Adams, Jiang Wang, Rajan Prakash, Nagla Abdel Karim

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Hepatic epithelioid hemangioendothelioma (HEHE) is a rare hepatic vascular tumor that represents a diagnostic challenge. The rarity of this neoplasm precludes establishment of a standard-ofcare treatment. Risk factors for HEHE are not well-known. Liver transplant remains the most common therapeutic modality for nonmetastatic disease. This article describes a patient who presented with abdominal pain, fatigue, poor appetite, and weight loss. Genetic testing showed that the patient was homozygous for C282Y consistent with hereditary hemochromatosis, and liver biopsy was consistent with malignant epithelioid hemangioendothelioma. The patient was referred for a liver transplant but was deemed inappropriate for transplant secondary to peritoneal studding, with frozen-section analysis showing metastatic disease at the time of surgery.

Original languageEnglish (US)
Pages (from-to)1203-1207
Number of pages5
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology

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