Hepatitis viruses and the MAPK pathway: Is this a survival strategy?

Milena Panteva, Hasan Korkaya, Shahid Jameel

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell interactions. New insights into the molecular basis of viral hepatitis reveal that three of these agents - the hepatitis B, C and E viruses (HBV, HCV and HEV) modulate the mitogen-activated protein kinase (MAPK) signaling pathway. In this review we briefly describe the structural organization of the MAPK cascade and emphasize its importance as a central pathway in the signaling network. Selected mechanisms through which HBV, HCV and HEV proteins target various steps in the MAPK pathway are discussed and used to propose a pro-survival outcome for the host cell. In addition, we offer an insight into how the common theme of MAPK activation and its downstream effects may be used to rationalize the different outcomes of hepatitis B, C and E.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalVirus Research
Volume92
Issue number2
DOIs
StatePublished - Apr 1 2003

Fingerprint

Hepatitis Viruses
Mitogen-Activated Protein Kinases
Hepatitis E
Hepatitis E virus
Hepatitis C
Hepatitis B
Hepatitis B virus
Cell Communication
Hepacivirus
Hepatitis
Necrosis
Viruses
Inflammation
Liver
Infection
Proteins

Keywords

  • Hepatitis virus
  • Hepatocellular carcinoma
  • Viral hepatitis

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Hepatitis viruses and the MAPK pathway : Is this a survival strategy? / Panteva, Milena; Korkaya, Hasan; Jameel, Shahid.

In: Virus Research, Vol. 92, No. 2, 01.04.2003, p. 131-140.

Research output: Contribution to journalReview article

Panteva, Milena ; Korkaya, Hasan ; Jameel, Shahid. / Hepatitis viruses and the MAPK pathway : Is this a survival strategy?. In: Virus Research. 2003 ; Vol. 92, No. 2. pp. 131-140.
@article{2fc750914a594311aa58aaf71d1eac31,
title = "Hepatitis viruses and the MAPK pathway: Is this a survival strategy?",
abstract = "The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell interactions. New insights into the molecular basis of viral hepatitis reveal that three of these agents - the hepatitis B, C and E viruses (HBV, HCV and HEV) modulate the mitogen-activated protein kinase (MAPK) signaling pathway. In this review we briefly describe the structural organization of the MAPK cascade and emphasize its importance as a central pathway in the signaling network. Selected mechanisms through which HBV, HCV and HEV proteins target various steps in the MAPK pathway are discussed and used to propose a pro-survival outcome for the host cell. In addition, we offer an insight into how the common theme of MAPK activation and its downstream effects may be used to rationalize the different outcomes of hepatitis B, C and E.",
keywords = "Hepatitis virus, Hepatocellular carcinoma, Viral hepatitis",
author = "Milena Panteva and Hasan Korkaya and Shahid Jameel",
year = "2003",
month = "4",
day = "1",
doi = "10.1016/S0168-1702(02)00356-8",
language = "English (US)",
volume = "92",
pages = "131--140",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Hepatitis viruses and the MAPK pathway

T2 - Is this a survival strategy?

AU - Panteva, Milena

AU - Korkaya, Hasan

AU - Jameel, Shahid

PY - 2003/4/1

Y1 - 2003/4/1

N2 - The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell interactions. New insights into the molecular basis of viral hepatitis reveal that three of these agents - the hepatitis B, C and E viruses (HBV, HCV and HEV) modulate the mitogen-activated protein kinase (MAPK) signaling pathway. In this review we briefly describe the structural organization of the MAPK cascade and emphasize its importance as a central pathway in the signaling network. Selected mechanisms through which HBV, HCV and HEV proteins target various steps in the MAPK pathway are discussed and used to propose a pro-survival outcome for the host cell. In addition, we offer an insight into how the common theme of MAPK activation and its downstream effects may be used to rationalize the different outcomes of hepatitis B, C and E.

AB - The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell interactions. New insights into the molecular basis of viral hepatitis reveal that three of these agents - the hepatitis B, C and E viruses (HBV, HCV and HEV) modulate the mitogen-activated protein kinase (MAPK) signaling pathway. In this review we briefly describe the structural organization of the MAPK cascade and emphasize its importance as a central pathway in the signaling network. Selected mechanisms through which HBV, HCV and HEV proteins target various steps in the MAPK pathway are discussed and used to propose a pro-survival outcome for the host cell. In addition, we offer an insight into how the common theme of MAPK activation and its downstream effects may be used to rationalize the different outcomes of hepatitis B, C and E.

KW - Hepatitis virus

KW - Hepatocellular carcinoma

KW - Viral hepatitis

UR - http://www.scopus.com/inward/record.url?scp=0037383040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037383040&partnerID=8YFLogxK

U2 - 10.1016/S0168-1702(02)00356-8

DO - 10.1016/S0168-1702(02)00356-8

M3 - Review article

C2 - 12686421

AN - SCOPUS:0037383040

VL - 92

SP - 131

EP - 140

JO - Virus Research

JF - Virus Research

SN - 0168-1702

IS - 2

ER -