Hepatoprotective activity of Feronia limonia root

Mahendra Jain, Rakhee Kapadia, Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Ranjitsinh V. Devkar, Shri H. Mishra

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives The aim of this study was to evaluate the hepatoprotective potential of a methanolic extract and of marmesin isolated from the root bark of Feronia limonia. Methods Activity levels of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), cell viability and cell death were evaluated in HepG2 cells (human liver hepatoma cells) treated with CCl 4 in the presence or absence of F. limonia extract or marmesin. Plasma activity levels of AST, ALT, bilirubin, alkaline phosphatase, protein, hepatic antioxidants, lipid peroxidation and histopathological evaluations were carried out in rats treated with CCl 4 alone or co-supplemented with F. limonia extract or marmesin in a dose-dependent manner. Key findings In-vitro co-supplementation of F. limonia methanolic extract or marmesin significantly minimized alteration in levels of AST and ALT and improved cell viability. Oral administration of F. limonia methanolic extract or marmesin significantly prevented CCl 4-induced elevation in the plasma markers of hepatic damage and hepatic lipid peroxidation and a decrease in hepatic antioxidants. In-vivo hepatoprotective potential of F. limonia methanolic extract and marmesin was evident from the minimal alterations in the histoarchitecture of liver. Conclusions This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.

Original languageEnglish (US)
Pages (from-to)888-896
Number of pages9
JournalJournal of Pharmacy and Pharmacology
Volume64
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Plumbaginaceae
Liver
Aspartic Acid
Alanine
Lipid Peroxidation
Cell Survival
Antioxidants
Hep G2 Cells
marmesin
Bilirubin
Alkaline Phosphatase
Oral Administration
Hepatocellular Carcinoma
Cell Death

Keywords

  • Feronia limonia root bark
  • HepG2 cells
  • carbon tetrachloride
  • marmesin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Hepatoprotective activity of Feronia limonia root. / Jain, Mahendra; Kapadia, Rakhee; Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh V.; Mishra, Shri H.

In: Journal of Pharmacy and Pharmacology, Vol. 64, No. 6, 01.06.2012, p. 888-896.

Research output: Contribution to journalArticle

Jain, Mahendra ; Kapadia, Rakhee ; Jadeja, Ravirajsinh N. ; Thounaojam, Menaka C. ; Devkar, Ranjitsinh V. ; Mishra, Shri H. / Hepatoprotective activity of Feronia limonia root. In: Journal of Pharmacy and Pharmacology. 2012 ; Vol. 64, No. 6. pp. 888-896.
@article{6d948b9b2e034946b16d80364a57cd77,
title = "Hepatoprotective activity of Feronia limonia root",
abstract = "Objectives The aim of this study was to evaluate the hepatoprotective potential of a methanolic extract and of marmesin isolated from the root bark of Feronia limonia. Methods Activity levels of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), cell viability and cell death were evaluated in HepG2 cells (human liver hepatoma cells) treated with CCl 4 in the presence or absence of F. limonia extract or marmesin. Plasma activity levels of AST, ALT, bilirubin, alkaline phosphatase, protein, hepatic antioxidants, lipid peroxidation and histopathological evaluations were carried out in rats treated with CCl 4 alone or co-supplemented with F. limonia extract or marmesin in a dose-dependent manner. Key findings In-vitro co-supplementation of F. limonia methanolic extract or marmesin significantly minimized alteration in levels of AST and ALT and improved cell viability. Oral administration of F. limonia methanolic extract or marmesin significantly prevented CCl 4-induced elevation in the plasma markers of hepatic damage and hepatic lipid peroxidation and a decrease in hepatic antioxidants. In-vivo hepatoprotective potential of F. limonia methanolic extract and marmesin was evident from the minimal alterations in the histoarchitecture of liver. Conclusions This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.",
keywords = "Feronia limonia root bark, HepG2 cells, carbon tetrachloride, marmesin",
author = "Mahendra Jain and Rakhee Kapadia and Jadeja, {Ravirajsinh N.} and Thounaojam, {Menaka C.} and Devkar, {Ranjitsinh V.} and Mishra, {Shri H.}",
year = "2012",
month = "6",
day = "1",
doi = "10.1111/j.2042-7158.2012.01481.x",
language = "English (US)",
volume = "64",
pages = "888--896",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "6",

}

TY - JOUR

T1 - Hepatoprotective activity of Feronia limonia root

AU - Jain, Mahendra

AU - Kapadia, Rakhee

AU - Jadeja, Ravirajsinh N.

AU - Thounaojam, Menaka C.

AU - Devkar, Ranjitsinh V.

AU - Mishra, Shri H.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Objectives The aim of this study was to evaluate the hepatoprotective potential of a methanolic extract and of marmesin isolated from the root bark of Feronia limonia. Methods Activity levels of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), cell viability and cell death were evaluated in HepG2 cells (human liver hepatoma cells) treated with CCl 4 in the presence or absence of F. limonia extract or marmesin. Plasma activity levels of AST, ALT, bilirubin, alkaline phosphatase, protein, hepatic antioxidants, lipid peroxidation and histopathological evaluations were carried out in rats treated with CCl 4 alone or co-supplemented with F. limonia extract or marmesin in a dose-dependent manner. Key findings In-vitro co-supplementation of F. limonia methanolic extract or marmesin significantly minimized alteration in levels of AST and ALT and improved cell viability. Oral administration of F. limonia methanolic extract or marmesin significantly prevented CCl 4-induced elevation in the plasma markers of hepatic damage and hepatic lipid peroxidation and a decrease in hepatic antioxidants. In-vivo hepatoprotective potential of F. limonia methanolic extract and marmesin was evident from the minimal alterations in the histoarchitecture of liver. Conclusions This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.

AB - Objectives The aim of this study was to evaluate the hepatoprotective potential of a methanolic extract and of marmesin isolated from the root bark of Feronia limonia. Methods Activity levels of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT), cell viability and cell death were evaluated in HepG2 cells (human liver hepatoma cells) treated with CCl 4 in the presence or absence of F. limonia extract or marmesin. Plasma activity levels of AST, ALT, bilirubin, alkaline phosphatase, protein, hepatic antioxidants, lipid peroxidation and histopathological evaluations were carried out in rats treated with CCl 4 alone or co-supplemented with F. limonia extract or marmesin in a dose-dependent manner. Key findings In-vitro co-supplementation of F. limonia methanolic extract or marmesin significantly minimized alteration in levels of AST and ALT and improved cell viability. Oral administration of F. limonia methanolic extract or marmesin significantly prevented CCl 4-induced elevation in the plasma markers of hepatic damage and hepatic lipid peroxidation and a decrease in hepatic antioxidants. In-vivo hepatoprotective potential of F. limonia methanolic extract and marmesin was evident from the minimal alterations in the histoarchitecture of liver. Conclusions This has been the first scientific report on the hepatoprotective potential of F. limonia root bark methanolic extract and marmesin.

KW - Feronia limonia root bark

KW - HepG2 cells

KW - carbon tetrachloride

KW - marmesin

UR - http://www.scopus.com/inward/record.url?scp=84861098489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861098489&partnerID=8YFLogxK

U2 - 10.1111/j.2042-7158.2012.01481.x

DO - 10.1111/j.2042-7158.2012.01481.x

M3 - Article

C2 - 22571268

AN - SCOPUS:84861098489

VL - 64

SP - 888

EP - 896

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 6

ER -