Abstract
A number of family studies in the 1960s and 1970s showed that a familial tendency to high (or low) blood pressure is established early in life. However, it remained unclear whether shared genes or shared environment caused the blood pressure aggregation within families. Classically, special study designs such as adoption or twin studies are necessary to effectively discriminate genetic from shared environmental influences. Furthermore, estimates of the relative influence of genetic and environmental factors derived from cross-sectional studies do not provide information on underlying genetic and environmental sources of continuity and change in the development of (high) blood pressure from childhood onward. The aim of the current chapter, therefore, is to review the available literature of genetically informative epidemiologic studies to address two issues: the potential causes of familial aggregation of blood pressure and the age dependency of genetic or environmental sources of blood pressure variation (and covariation) within and between families.
| Original language | English (US) |
|---|---|
| Title of host publication | Pediatric Hypertension |
| Publisher | Springer International Publishing |
| Pages | 159-176 |
| Number of pages | 18 |
| ISBN (Electronic) | 9783319311074 |
| ISBN (Print) | 9783319311067 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Age dependency
- Family environment
- Family study
- Heritability
- Twin study
ASJC Scopus subject areas
- Medicine(all)
Cite this
Heritability and familial aggregation of blood pressure. / Wang, Xiaoling; Snieder, Harold.
Pediatric Hypertension. Springer International Publishing, 2018. p. 159-176.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Heritability and familial aggregation of blood pressure
AU - Wang, Xiaoling
AU - Snieder, Harold
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A number of family studies in the 1960s and 1970s showed that a familial tendency to high (or low) blood pressure is established early in life. However, it remained unclear whether shared genes or shared environment caused the blood pressure aggregation within families. Classically, special study designs such as adoption or twin studies are necessary to effectively discriminate genetic from shared environmental influences. Furthermore, estimates of the relative influence of genetic and environmental factors derived from cross-sectional studies do not provide information on underlying genetic and environmental sources of continuity and change in the development of (high) blood pressure from childhood onward. The aim of the current chapter, therefore, is to review the available literature of genetically informative epidemiologic studies to address two issues: the potential causes of familial aggregation of blood pressure and the age dependency of genetic or environmental sources of blood pressure variation (and covariation) within and between families.
AB - A number of family studies in the 1960s and 1970s showed that a familial tendency to high (or low) blood pressure is established early in life. However, it remained unclear whether shared genes or shared environment caused the blood pressure aggregation within families. Classically, special study designs such as adoption or twin studies are necessary to effectively discriminate genetic from shared environmental influences. Furthermore, estimates of the relative influence of genetic and environmental factors derived from cross-sectional studies do not provide information on underlying genetic and environmental sources of continuity and change in the development of (high) blood pressure from childhood onward. The aim of the current chapter, therefore, is to review the available literature of genetically informative epidemiologic studies to address two issues: the potential causes of familial aggregation of blood pressure and the age dependency of genetic or environmental sources of blood pressure variation (and covariation) within and between families.
KW - Age dependency
KW - Family environment
KW - Family study
KW - Heritability
KW - Twin study
UR - http://www.scopus.com/inward/record.url?scp=85046424959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046424959&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-31107-4_14
DO - 10.1007/978-3-319-31107-4_14
M3 - Chapter
AN - SCOPUS:85046424959
SN - 9783319311067
SP - 159
EP - 176
BT - Pediatric Hypertension
PB - Springer International Publishing
ER -