Heritability of carotid intima-media thickness: A twin study

Jinying Zhao, Faiz A. Cheema, J. Douglas Bremner, Jack Goldberg, Shaoyong Su, Harold Snieder, Carisa Maisano, Linda Jones, Farhan Javed, Nancy Murrah, Ngoc Anh Le, Viola Vaccarino

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Objective: To estimate the heritability of carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, independent of traditional coronary risk factors. Methods and results: We performed a classical twin study of carotid IMT using 98 middle-aged male twin pairs, 58 monozygotic (MZ) and 40 dizygotic (DZ) pairs, from the Vietnam Era Twin Registry. All twins were free of overt cardiovascular disease. Carotid IMT was measured by ultrasound. Bivariate and multivariate analyses were used to determine the association between traditional cardiovascular risk factors and carotid IMT. Intraclass correlation coefficients and genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in carotid IMT. In our sample, the mean of the maximum carotid IMT was 0.75 ± 0.11. Age, systolic blood pressure and HDL were significantly associated with carotid IMT. The intraclass correlation coefficient for carotid IMT was larger in MZ (0.66; 95% confidence interval [CI], 0.62-0.69) than in DZ twins (0.37; 95% CI, 0.29-0.44), and the unadjusted heritability was 0.69 (95% CI, 0.54-0.79). After adjusting for traditional coronary risk factors, the heritability of carotid IMT was slightly reduced but still of considerable magnitude (0.59; 95% CI, 0.39-0.73). Conclusion: Genetic factors have a substantial influence on the variation of carotid IMT. Most of this genetic effect occurs through pathways independent of traditional coronary risk factors.

Original languageEnglish (US)
Pages (from-to)814-820
Number of pages7
JournalAtherosclerosis
Volume197
Issue number2
DOIs
StatePublished - Apr 2008

Keywords

  • Atherosclerosis
  • Carotid intima-media thickness
  • Heritability
  • Twin study

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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