Heritability of flow-mediated dilation: A twin study

J. Zhao, F. A. Cheema, U. Reddy, J. D. Bremner, S. Su, J. Goldberg, H. Snieder, Viola Vaccarino

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Endothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events. Objective: To estimate the heritability of brachial artery FMD using a twin design. Methods: We estimated the heritability of FMD using 94 middle-aged male twin pairs. FMD was measured by ultrasound, and traditional coronary heart disease risk factors were measured. Genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in FMD. Results: The mean age of the twin participants was 54.9 ± 2.8years. The mean FMD was 0.047 ± 0.030. The intraclass correlation coefficient was higher in MZ twins [0.38, 95%; confidence interval (CI) 0.32-0.43] than in DZ twins (0.19, 95% CI 0.11-0.26), suggesting a role of genetic influence in FMD variation. Structural equation modeling showed that both genetic and unique environmental factors contributed significantly to the variation in FMD. The crude FMD heritability was 0.37 (95% CI 0.15-0.54). After adjustment for traditional cardiovascular risk factors, including age, total cholesterol, blood pressure, and body mass index, the heritability of FMD was 39% (95% CI 0.18-0.56). The remaining variation in FMD could be explained by individual-specific environment. Conclusion: This is the first study using twins to estimate the relative contributions of genetics and environment to the variation in FMD in a US population. Our results demonstrate a moderate genetic effect on brachial artery FMD, independent of traditional coronary risk factors. Our data also highlight the importance of unique environment on the variability in FMD.

Original languageEnglish (US)
Pages (from-to)2386-2392
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2007

Fingerprint

Twin Studies
Dilatation
Brachial Artery
Confidence Intervals
Genetic Techniques
Vascular Diseases
Coronary Disease

Keywords

  • Atherosclerosis
  • Brachial artery
  • Flow-mediated dilation
  • Heritability
  • Twin study

ASJC Scopus subject areas

  • Hematology

Cite this

Zhao, J., Cheema, F. A., Reddy, U., Bremner, J. D., Su, S., Goldberg, J., ... Vaccarino, V. (2007). Heritability of flow-mediated dilation: A twin study. Journal of Thrombosis and Haemostasis, 5(12), 2386-2392. https://doi.org/10.1111/j.1538-7836.2007.02760.x

Heritability of flow-mediated dilation : A twin study. / Zhao, J.; Cheema, F. A.; Reddy, U.; Bremner, J. D.; Su, S.; Goldberg, J.; Snieder, H.; Vaccarino, Viola.

In: Journal of Thrombosis and Haemostasis, Vol. 5, No. 12, 01.12.2007, p. 2386-2392.

Research output: Contribution to journalArticle

Zhao, J, Cheema, FA, Reddy, U, Bremner, JD, Su, S, Goldberg, J, Snieder, H & Vaccarino, V 2007, 'Heritability of flow-mediated dilation: A twin study', Journal of Thrombosis and Haemostasis, vol. 5, no. 12, pp. 2386-2392. https://doi.org/10.1111/j.1538-7836.2007.02760.x
Zhao, J. ; Cheema, F. A. ; Reddy, U. ; Bremner, J. D. ; Su, S. ; Goldberg, J. ; Snieder, H. ; Vaccarino, Viola. / Heritability of flow-mediated dilation : A twin study. In: Journal of Thrombosis and Haemostasis. 2007 ; Vol. 5, No. 12. pp. 2386-2392.
@article{b403806b7c454f158b566dd0bfc874b4,
title = "Heritability of flow-mediated dilation: A twin study",
abstract = "Background: Endothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events. Objective: To estimate the heritability of brachial artery FMD using a twin design. Methods: We estimated the heritability of FMD using 94 middle-aged male twin pairs. FMD was measured by ultrasound, and traditional coronary heart disease risk factors were measured. Genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in FMD. Results: The mean age of the twin participants was 54.9 ± 2.8years. The mean FMD was 0.047 ± 0.030. The intraclass correlation coefficient was higher in MZ twins [0.38, 95{\%}; confidence interval (CI) 0.32-0.43] than in DZ twins (0.19, 95{\%} CI 0.11-0.26), suggesting a role of genetic influence in FMD variation. Structural equation modeling showed that both genetic and unique environmental factors contributed significantly to the variation in FMD. The crude FMD heritability was 0.37 (95{\%} CI 0.15-0.54). After adjustment for traditional cardiovascular risk factors, including age, total cholesterol, blood pressure, and body mass index, the heritability of FMD was 39{\%} (95{\%} CI 0.18-0.56). The remaining variation in FMD could be explained by individual-specific environment. Conclusion: This is the first study using twins to estimate the relative contributions of genetics and environment to the variation in FMD in a US population. Our results demonstrate a moderate genetic effect on brachial artery FMD, independent of traditional coronary risk factors. Our data also highlight the importance of unique environment on the variability in FMD.",
keywords = "Atherosclerosis, Brachial artery, Flow-mediated dilation, Heritability, Twin study",
author = "J. Zhao and Cheema, {F. A.} and U. Reddy and Bremner, {J. D.} and S. Su and J. Goldberg and H. Snieder and Viola Vaccarino",
year = "2007",
month = "12",
day = "1",
doi = "10.1111/j.1538-7836.2007.02760.x",
language = "English (US)",
volume = "5",
pages = "2386--2392",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Heritability of flow-mediated dilation

T2 - A twin study

AU - Zhao, J.

AU - Cheema, F. A.

AU - Reddy, U.

AU - Bremner, J. D.

AU - Su, S.

AU - Goldberg, J.

AU - Snieder, H.

AU - Vaccarino, Viola

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Background: Endothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events. Objective: To estimate the heritability of brachial artery FMD using a twin design. Methods: We estimated the heritability of FMD using 94 middle-aged male twin pairs. FMD was measured by ultrasound, and traditional coronary heart disease risk factors were measured. Genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in FMD. Results: The mean age of the twin participants was 54.9 ± 2.8years. The mean FMD was 0.047 ± 0.030. The intraclass correlation coefficient was higher in MZ twins [0.38, 95%; confidence interval (CI) 0.32-0.43] than in DZ twins (0.19, 95% CI 0.11-0.26), suggesting a role of genetic influence in FMD variation. Structural equation modeling showed that both genetic and unique environmental factors contributed significantly to the variation in FMD. The crude FMD heritability was 0.37 (95% CI 0.15-0.54). After adjustment for traditional cardiovascular risk factors, including age, total cholesterol, blood pressure, and body mass index, the heritability of FMD was 39% (95% CI 0.18-0.56). The remaining variation in FMD could be explained by individual-specific environment. Conclusion: This is the first study using twins to estimate the relative contributions of genetics and environment to the variation in FMD in a US population. Our results demonstrate a moderate genetic effect on brachial artery FMD, independent of traditional coronary risk factors. Our data also highlight the importance of unique environment on the variability in FMD.

AB - Background: Endothelial dysfunction assessed by brachial artery flow-mediated dilation (FMD) is a marker for early atherosclerotic vascular disease and future cardiovascular events. Objective: To estimate the heritability of brachial artery FMD using a twin design. Methods: We estimated the heritability of FMD using 94 middle-aged male twin pairs. FMD was measured by ultrasound, and traditional coronary heart disease risk factors were measured. Genetic modeling techniques were used to determine the relative contributions of genes and environment to the variation in FMD. Results: The mean age of the twin participants was 54.9 ± 2.8years. The mean FMD was 0.047 ± 0.030. The intraclass correlation coefficient was higher in MZ twins [0.38, 95%; confidence interval (CI) 0.32-0.43] than in DZ twins (0.19, 95% CI 0.11-0.26), suggesting a role of genetic influence in FMD variation. Structural equation modeling showed that both genetic and unique environmental factors contributed significantly to the variation in FMD. The crude FMD heritability was 0.37 (95% CI 0.15-0.54). After adjustment for traditional cardiovascular risk factors, including age, total cholesterol, blood pressure, and body mass index, the heritability of FMD was 39% (95% CI 0.18-0.56). The remaining variation in FMD could be explained by individual-specific environment. Conclusion: This is the first study using twins to estimate the relative contributions of genetics and environment to the variation in FMD in a US population. Our results demonstrate a moderate genetic effect on brachial artery FMD, independent of traditional coronary risk factors. Our data also highlight the importance of unique environment on the variability in FMD.

KW - Atherosclerosis

KW - Brachial artery

KW - Flow-mediated dilation

KW - Heritability

KW - Twin study

UR - http://www.scopus.com/inward/record.url?scp=36348947443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36348947443&partnerID=8YFLogxK

U2 - 10.1111/j.1538-7836.2007.02760.x

DO - 10.1111/j.1538-7836.2007.02760.x

M3 - Article

C2 - 17848176

AN - SCOPUS:36348947443

VL - 5

SP - 2386

EP - 2392

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 12

ER -