Heritability of functioning in families with schizophrenia in relation to neurocognition

R. M. Savage, H. W. Wiener, V. Nimgaonkar, B. Devlin, M. E. Calkins, R. E. Gur, J. O'Jile, L. D. Bradford, N. Edwards, J. Kwentus, T. Allen, Joseph Patrick McEvoy, H. Nasrallah, Alberto Santos, T. Aduroja, A. Lahti, R. S. May, L. Montgomery-Barefield, R. C.P. Go

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The role of daily functioning is an integral part of the schizophrenia (SZ) phenotype and deficits in this trait appear to be present in both affected persons and some unaffected relatives; hence we have examined its heritability in our cohort of African American schizophrenia families. There is now ample evidence that deficits in cognitive function can impact family members who are not themselves diagnosed with SZ; there is some, but less evidence that role function behaves likewise. We evaluate whether role function tends to "run in families" who were ascertained because they contain an African American proband diagnosed with SZ. Methods: We analyzed heritability for selected traits related to daily function, employment, living situation, marital status, and Global Assessment Scale (GAS) score; modeling age, gender, along with neurocognition and diagnosis as covariates in a family based African-American sample (N = 2488 individuals including 979 probands). Results: Measures of role function were heritable in models including neurocognitive domains and factor analytically derived neurocognitive summary scores and demographics as covariates; the most heritable estimate was obtained from the current GAS scores (h2 = 0.72). Neurocognition was not a significant contributor to heritability of role function. Conclusions: Commonly assessed demographic and clinical indicators of functioning are heritable with a global rating of functioning being the most heritable. Measures of neurocognition had little impact on heritability of functioning overall. The family covariance for functioning, reflected in its heritability, supports the concept that interventions at the family level, such as evidenced-based family psychoeducation may be beneficial in schizophrenia.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalSchizophrenia Research
Volume139
Issue number1-3
DOIs
StatePublished - Aug 1 2012

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Schizophrenia
African Americans
Demography
Marital Status
Cognition
Phenotype

Keywords

  • Families
  • Heritability
  • Neurocognition

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Savage, R. M., Wiener, H. W., Nimgaonkar, V., Devlin, B., Calkins, M. E., Gur, R. E., ... Go, R. C. P. (2012). Heritability of functioning in families with schizophrenia in relation to neurocognition. Schizophrenia Research, 139(1-3), 105-109. https://doi.org/10.1016/j.schres.2012.04.015

Heritability of functioning in families with schizophrenia in relation to neurocognition. / Savage, R. M.; Wiener, H. W.; Nimgaonkar, V.; Devlin, B.; Calkins, M. E.; Gur, R. E.; O'Jile, J.; Bradford, L. D.; Edwards, N.; Kwentus, J.; Allen, T.; McEvoy, Joseph Patrick; Nasrallah, H.; Santos, Alberto; Aduroja, T.; Lahti, A.; May, R. S.; Montgomery-Barefield, L.; Go, R. C.P.

In: Schizophrenia Research, Vol. 139, No. 1-3, 01.08.2012, p. 105-109.

Research output: Contribution to journalArticle

Savage, RM, Wiener, HW, Nimgaonkar, V, Devlin, B, Calkins, ME, Gur, RE, O'Jile, J, Bradford, LD, Edwards, N, Kwentus, J, Allen, T, McEvoy, JP, Nasrallah, H, Santos, A, Aduroja, T, Lahti, A, May, RS, Montgomery-Barefield, L & Go, RCP 2012, 'Heritability of functioning in families with schizophrenia in relation to neurocognition', Schizophrenia Research, vol. 139, no. 1-3, pp. 105-109. https://doi.org/10.1016/j.schres.2012.04.015
Savage RM, Wiener HW, Nimgaonkar V, Devlin B, Calkins ME, Gur RE et al. Heritability of functioning in families with schizophrenia in relation to neurocognition. Schizophrenia Research. 2012 Aug 1;139(1-3):105-109. https://doi.org/10.1016/j.schres.2012.04.015
Savage, R. M. ; Wiener, H. W. ; Nimgaonkar, V. ; Devlin, B. ; Calkins, M. E. ; Gur, R. E. ; O'Jile, J. ; Bradford, L. D. ; Edwards, N. ; Kwentus, J. ; Allen, T. ; McEvoy, Joseph Patrick ; Nasrallah, H. ; Santos, Alberto ; Aduroja, T. ; Lahti, A. ; May, R. S. ; Montgomery-Barefield, L. ; Go, R. C.P. / Heritability of functioning in families with schizophrenia in relation to neurocognition. In: Schizophrenia Research. 2012 ; Vol. 139, No. 1-3. pp. 105-109.
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AU - Allen, T.

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