Herpes simplex virus binding and entry modulate cell surface protein mobility

K. S. Rosenthal, M. D. Leuther, B. G. Barisas

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Fluorescence photobleaching recovery measurements showed that herpes virus type 1 attachment to target cells rapidly induced an anchorage modulation of cell surface protein mobility, an activity mediated by the cytoskeleton and associated with the multivalent attachment of other ligands (e.g., cells, lectins, or anti-immunoglobulin) to cell surfaces. The restriction in cell surface protein mobility was released concurrently with virus penetration. The effects of attachment and penetration on cell surface protein mobility and cytoskeletal function are some of the earliest cellular changes induced by herpes simplex virus infection.

Original languageEnglish (US)
Pages (from-to)980-983
Number of pages4
JournalJournal of Virology
Issue number3
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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