Heterosis for brain myelin content in mice

Thomas N. Seyfried, Robert K. Yu

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Biochemical evidence of heterosis (hybrid vigor) for brain myelin content is presented. The concentrations of cerebroside and GM1 ganglioside, two glycolipids known to be abundant in myelin, were higher in the brains of (C57BL/6J × DBA/2J) F1 hybrids than in the brains of either parental strain. Furthermore, brain water content, which is known to be inversely related to myelin content, was lower in the F1 hybrids, especially during the most active period of myelin synthesis. Heterosis was not observed, however, for total brain ganglioside concentration. Additionally, the results do not substantiate a direct developmental-genetic relationship between brain myelin content and susceptibility to audiogenic seizures.

Original languageEnglish (US)
Pages (from-to)1229-1238
Number of pages10
JournalBiochemical Genetics
Volume18
Issue number11-12
DOIs
StatePublished - Dec 1980
Externally publishedYes

Keywords

  • audiogenic seizures
  • gangliosides
  • heterosis
  • myelinogenesis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

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