Hexagonal boron nitrides reduce the oxidative stress on cells

Irem Culha Taskin, Ozlem Sen, Melis Emanet, Mustafa Culha, Bayram Yilmaz

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The molecular stress caused by a drug administered to treat a disorder on healthy cells appears as a side effect. In this study, we aim to understand the potential of hexagonal boron nitrides (hBNs) as a therapeutic agent to relieve the cellular stress exerted by drugs. First, the cytotoxicity of hBNs and their possible degradation product, boric acid (BA), on the embryonic mouse hippocampal cell line mHippo E-14 was assessed in a wide concentration range (4.4-440 μg ml-1) of boron including hBNs and BA for 24 and 72 h exposure. Then, cell cycle, reactive oxygen species generation, cell death mechanism and apoptotic body formation in nuclei with hBN and BA exposure were evaluated at increased concentrations and incubation times. Finally, the cells, exposed to doxorubicin (DOX), an anti-cancer chemotherapy drug, to exert oxidative stress, were treated with hBNs and BA. The results indicate that hBNs decrease the oxidative stress at the concentrations that are nontoxic to cells. The study suggests that hBNs can open new venues for their investigation to reduce or eliminate the adverse effects of toxic drugs used in the treatment of several fatal diseases including neurological disorders and cancer with their slow degradation feature.

Original languageEnglish (US)
Article number215101
JournalNanotechnology
Volume31
Issue number21
DOIs
StatePublished - May 22 2020
Externally publishedYes

Keywords

  • Boric acid
  • Cytotoxicity
  • Doxorubicin
  • Hexagonal boron nitrides

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Hexagonal boron nitrides reduce the oxidative stress on cells'. Together they form a unique fingerprint.

Cite this