High-density multielectrode array with independently maneuverable electrodes and silicone oil fluid isolation system for chronic recording from macaque monkey

Naohisa Miyakawa, Noriko Katsumata, David T. Blake, Michael M. Merzenich, Manabu Tanifuji

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Chronic multielectrode recording has become a widely used technique in the past twenty years, and there are multiple standardized methods. As for recording with high-density array, the most common method in macaque monkeys is to use a subdural array with fixed electrodes. In this study, we utilized the electrode array with independently maneuverable electrodes arranged in high-density, which was originally designed for use on small animals, and redesigned it for use on macaque monkeys while maintaining the virtues of maneuverability and high-density. We successfully recorded single and multiunit activities from up to 49 channels in the V1 and inferior temporal (IT) cortex of macaque monkeys. The main change in the surgical procedure was to remove a 5. mm diameter area of dura mater. The main changes in the design were (1) to have a constricted layer of heavy silicone oil at the interface with the animal to isolate the electrical circuit from the cerebrospinal fluid, and (2) to have a fluid draining system that can shunt any potential postsurgical subcranial exudate to the extracranial space.

Original languageEnglish (US)
Pages (from-to)114-124
Number of pages11
JournalJournal of Neuroscience Methods
Volume211
Issue number1
DOIs
StatePublished - Oct 15 2012

Keywords

  • Chronic
  • Cortex
  • Drain
  • Implant
  • Macaque
  • Multi-electrode array
  • Neuron
  • Unit recording

ASJC Scopus subject areas

  • Neuroscience(all)

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