High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents

Haidong Zhu, J. Bhagatwala, Norman K. Pollock, S. Parikh, B. Gutin, I. Stallmann-Jorgensen, J. Thomas, Gregory A Harshfield, Yanbin Dong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/objectives:Telomere shortening has an important role in cellular aging. However, the impact of high sodium intake, an important risk factor of age-related diseases, on telomere shortening remains unknown. Therefore, we examined the relationship between high dietary sodium intake and leukocyte telomere length (LTL), particularly in the context of obesity, as obesity increases salt sensitivity.Subjects/methods:LTL was determined by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% females, 49% African Americans). Dietary sodium intake was assessed by seven independent 24-h dietary recalls. We divided the sample into low sodium (mean 2388±522 mg per day) or high sodium groups (mean 4142±882 mg per day) based on the median value (3280.9 mg per day).Results:In the entire cohort, there was no significant association between sodium intake and LTL (r=-0.05, P=0.24). However, there was a significant interaction between sodium intake and obesity status (P=0.049). Further multiple linear regression analyses revealed that higher dietary sodium intake was associated with shorter LTL in the overweight/obese group (body mass index ≥85th percentile, β=-0.37, P=0.04), but not in the normal-weight group (β=0.01, P=0.93) after adjusting for multiple confounding factors. In the overweight/obese group, LTL was significantly shorter in the high sodium intake subjects vs low sodium intake subjects (1.24±0.22 vs. 1.32±0.20, P=0.02), but not the normal-weight group (1.29±0.24 vs 1.30±0.24, P=0.69).Conclusions:Higher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.

Original languageEnglish (US)
Pages (from-to)1249-1253
Number of pages5
JournalInternational Journal of Obesity
Volume39
Issue number8
DOIs
StatePublished - Aug 6 2015

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Telomere
Leukocytes
Dietary Sodium
Sodium
Telomere Shortening
Obesity
Weights and Measures
Cell Aging
African Americans
Linear Models
Body Mass Index
Salts
Regression Analysis
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents. / Zhu, Haidong; Bhagatwala, J.; Pollock, Norman K.; Parikh, S.; Gutin, B.; Stallmann-Jorgensen, I.; Thomas, J.; Harshfield, Gregory A; Dong, Yanbin.

In: International Journal of Obesity, Vol. 39, No. 8, 06.08.2015, p. 1249-1253.

Research output: Contribution to journalArticle

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title = "High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents",
abstract = "Background/objectives:Telomere shortening has an important role in cellular aging. However, the impact of high sodium intake, an important risk factor of age-related diseases, on telomere shortening remains unknown. Therefore, we examined the relationship between high dietary sodium intake and leukocyte telomere length (LTL), particularly in the context of obesity, as obesity increases salt sensitivity.Subjects/methods:LTL was determined by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50{\%} females, 49{\%} African Americans). Dietary sodium intake was assessed by seven independent 24-h dietary recalls. We divided the sample into low sodium (mean 2388±522 mg per day) or high sodium groups (mean 4142±882 mg per day) based on the median value (3280.9 mg per day).Results:In the entire cohort, there was no significant association between sodium intake and LTL (r=-0.05, P=0.24). However, there was a significant interaction between sodium intake and obesity status (P=0.049). Further multiple linear regression analyses revealed that higher dietary sodium intake was associated with shorter LTL in the overweight/obese group (body mass index ≥85th percentile, β=-0.37, P=0.04), but not in the normal-weight group (β=0.01, P=0.93) after adjusting for multiple confounding factors. In the overweight/obese group, LTL was significantly shorter in the high sodium intake subjects vs low sodium intake subjects (1.24±0.22 vs. 1.32±0.20, P=0.02), but not the normal-weight group (1.29±0.24 vs 1.30±0.24, P=0.69).Conclusions:Higher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.",
author = "Haidong Zhu and J. Bhagatwala and Pollock, {Norman K.} and S. Parikh and B. Gutin and I. Stallmann-Jorgensen and J. Thomas and Harshfield, {Gregory A} and Yanbin Dong",
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T1 - High sodium intake is associated with short leukocyte telomere length in overweight and obese adolescents

AU - Zhu, Haidong

AU - Bhagatwala, J.

AU - Pollock, Norman K.

AU - Parikh, S.

AU - Gutin, B.

AU - Stallmann-Jorgensen, I.

AU - Thomas, J.

AU - Harshfield, Gregory A

AU - Dong, Yanbin

PY - 2015/8/6

Y1 - 2015/8/6

N2 - Background/objectives:Telomere shortening has an important role in cellular aging. However, the impact of high sodium intake, an important risk factor of age-related diseases, on telomere shortening remains unknown. Therefore, we examined the relationship between high dietary sodium intake and leukocyte telomere length (LTL), particularly in the context of obesity, as obesity increases salt sensitivity.Subjects/methods:LTL was determined by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% females, 49% African Americans). Dietary sodium intake was assessed by seven independent 24-h dietary recalls. We divided the sample into low sodium (mean 2388±522 mg per day) or high sodium groups (mean 4142±882 mg per day) based on the median value (3280.9 mg per day).Results:In the entire cohort, there was no significant association between sodium intake and LTL (r=-0.05, P=0.24). However, there was a significant interaction between sodium intake and obesity status (P=0.049). Further multiple linear regression analyses revealed that higher dietary sodium intake was associated with shorter LTL in the overweight/obese group (body mass index ≥85th percentile, β=-0.37, P=0.04), but not in the normal-weight group (β=0.01, P=0.93) after adjusting for multiple confounding factors. In the overweight/obese group, LTL was significantly shorter in the high sodium intake subjects vs low sodium intake subjects (1.24±0.22 vs. 1.32±0.20, P=0.02), but not the normal-weight group (1.29±0.24 vs 1.30±0.24, P=0.69).Conclusions:Higher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.

AB - Background/objectives:Telomere shortening has an important role in cellular aging. However, the impact of high sodium intake, an important risk factor of age-related diseases, on telomere shortening remains unknown. Therefore, we examined the relationship between high dietary sodium intake and leukocyte telomere length (LTL), particularly in the context of obesity, as obesity increases salt sensitivity.Subjects/methods:LTL was determined by a quantitative polymerase chain reaction method in 766 adolescents aged 14-18 years (50% females, 49% African Americans). Dietary sodium intake was assessed by seven independent 24-h dietary recalls. We divided the sample into low sodium (mean 2388±522 mg per day) or high sodium groups (mean 4142±882 mg per day) based on the median value (3280.9 mg per day).Results:In the entire cohort, there was no significant association between sodium intake and LTL (r=-0.05, P=0.24). However, there was a significant interaction between sodium intake and obesity status (P=0.049). Further multiple linear regression analyses revealed that higher dietary sodium intake was associated with shorter LTL in the overweight/obese group (body mass index ≥85th percentile, β=-0.37, P=0.04), but not in the normal-weight group (β=0.01, P=0.93) after adjusting for multiple confounding factors. In the overweight/obese group, LTL was significantly shorter in the high sodium intake subjects vs low sodium intake subjects (1.24±0.22 vs. 1.32±0.20, P=0.02), but not the normal-weight group (1.29±0.24 vs 1.30±0.24, P=0.69).Conclusions:Higher dietary sodium intake is associated with shorter telomere length in overweight and obese adolescents.

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DO - 10.1038/ijo.2015.51

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VL - 39

SP - 1249

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JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

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