Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)

Christopher J. Lynch, Gurmukh Singh, Theresa L. Whiteside, Gerald P. Rodnan, Thomas A. Medsger, Bruce S. Rabin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls;P<0.005, corrected P>0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls;P<0.005, corrected P<0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P<0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR1-negative patients (0.46 vs 0.18;P<0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype or HLA-DR5 antigen.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalJournal of Clinical Immunology
Volume2
Issue number4
DOIs
StatePublished - Oct 1 1982
Externally publishedYes

Fingerprint

Diffuse Scleroderma
Histocompatibility Antigens
Antigens
HLA-A Antigens
HLA-DR5 Antigen
HLA-B8 Antigen
HLA-DR3 Antigen
HLA-B Antigens
Centromere
Pulmonary Fibrosis
Haplotypes
Antibodies
Serum

Keywords

  • histocompatibility antigens
  • HLA antigens in PSS
  • Progressive systemic sclerosis (PSS)
  • scleroderma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lynch, C. J., Singh, G., Whiteside, T. L., Rodnan, G. P., Medsger, T. A., & Rabin, B. S. (1982). Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma). Journal of Clinical Immunology, 2(4), 314-318. https://doi.org/10.1007/BF00915073

Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma). / Lynch, Christopher J.; Singh, Gurmukh; Whiteside, Theresa L.; Rodnan, Gerald P.; Medsger, Thomas A.; Rabin, Bruce S.

In: Journal of Clinical Immunology, Vol. 2, No. 4, 01.10.1982, p. 314-318.

Research output: Contribution to journalArticle

Lynch, Christopher J. ; Singh, Gurmukh ; Whiteside, Theresa L. ; Rodnan, Gerald P. ; Medsger, Thomas A. ; Rabin, Bruce S. / Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma). In: Journal of Clinical Immunology. 1982 ; Vol. 2, No. 4. pp. 314-318.
@article{252a2804312544c6b0d96ce8708a6131,
title = "Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)",
abstract = "Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls;P<0.005, corrected P>0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls;P<0.005, corrected P<0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P<0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR1-negative patients (0.46 vs 0.18;P<0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype or HLA-DR5 antigen.",
keywords = "histocompatibility antigens, HLA antigens in PSS, Progressive systemic sclerosis (PSS), scleroderma",
author = "Lynch, {Christopher J.} and Gurmukh Singh and Whiteside, {Theresa L.} and Rodnan, {Gerald P.} and Medsger, {Thomas A.} and Rabin, {Bruce S.}",
year = "1982",
month = "10",
day = "1",
doi = "10.1007/BF00915073",
language = "English (US)",
volume = "2",
pages = "314--318",
journal = "Journal of Clinical Immunology",
issn = "0271-9142",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Histocompatibility antigens in progressive systemic sclerosis (PSS; scleroderma)

AU - Lynch, Christopher J.

AU - Singh, Gurmukh

AU - Whiteside, Theresa L.

AU - Rodnan, Gerald P.

AU - Medsger, Thomas A.

AU - Rabin, Bruce S.

PY - 1982/10/1

Y1 - 1982/10/1

N2 - Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls;P<0.005, corrected P>0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls;P<0.005, corrected P<0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P<0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR1-negative patients (0.46 vs 0.18;P<0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype or HLA-DR5 antigen.

AB - Patients with progressive systemic sclerosis (PSS; scleroderma) were typed for the HLA-A, -B, and -DR antigens. No significant differences in the frequencies of any HLA-A or -B antigen were found. In the subgroup of patients with PSS and diffuse scleroderma (PSS-DS), the frequency of Bw35 was increased (0.30 vs 0.17 in controls;P<0.005, corrected P>0.2). Although patients with PSS-DS also had an increased frequency of DR1 antigen (0.27 vs 0.12 in local controls;P<0.005, corrected P<0.05), no association between Bw35 and DR1 antigens could be detected. We found no increase in the frequencies of the DR3 or DR5 antigens in patients with PSS. However, in a subset of PSS patients with pulmonary fibrosis, an increase in DR3 and a decrease in DR4 antigens (P<0.005) were observed. Serum antibodies to centromere occurred more frequently in DR1-positive than DR1-negative patients (0.46 vs 0.18;P<0.005). This study of a large number of patients with PSS failed to confirm previously reported associations of PSS with the HLA-B8/DR3 haplotype or HLA-DR5 antigen.

KW - histocompatibility antigens

KW - HLA antigens in PSS

KW - Progressive systemic sclerosis (PSS)

KW - scleroderma

UR - http://www.scopus.com/inward/record.url?scp=0020382022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020382022&partnerID=8YFLogxK

U2 - 10.1007/BF00915073

DO - 10.1007/BF00915073

M3 - Article

VL - 2

SP - 314

EP - 318

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

SN - 0271-9142

IS - 4

ER -