Histone deacetylase inhibition promotes osteoblast maturation by altering the histone H4 epigenome and reduces akt phosphorylation

Amel Dudakovic, Jared M. Evans, Ying Li, Sumit Middha, Meghan Elizabeth McGee Lawrence, Andre J. Van Wijnen, Jennifer J. Westendorf

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Background:Histone deacetylase (HDAC) inhibition promotes bone formationin vitrovia undefined epigenetic events. Results:Microarray and ChIP-Seq analyses revealed genomic areas where H4 acetylation is altered by HDAC inhibitors and identified differentially regulated genes. Conclusion:Suberoylanilide hydroxamic acid increases H4 acetylation and suppresses phosphorylation of insulin/Akt signaling mediators in osteoblasts. Significance:Epigenetic profiling is a powerful means to gain mechanistic insights into bone anabolic processes.

Original languageEnglish (US)
Pages (from-to)28783-28791
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
Publication statusPublished - Oct 4 2013
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this