Histone deacetylases and cardiometabolic diseases

Kan Hui Yiew, Tapan K. Chatterjee, David Y. Hui, Neal L. Weintraub

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. Genetic and environmental factors are linked through epigenetic mechanisms to the pathogenesis of cardiometabolic disease. Post-translational modifications of histone tails, including acetylation and deacetylation, epigenetically alter chromatin structure and dictate cell-specific gene expression patterns. The histone deacetylase family comprises 18 members that regulate gene expression by altering the acetylation status of nucleosomal histones and by functioning as nuclear transcriptional corepressors. Histone deacetylases regulate key aspects of metabolism, inflammation, and vascular function pertinent to cardiometabolic disease in a cell- and tissue-specific manner. Histone deacetylases also likely play a role in the metabolic memory of diabetes mellitus, an important clinical aspect of the disease. Understanding the molecular, cellular, and physiological functions of histone deacetylases in cardiometabolic disease is expected to provide insight into disease pathogenesis, risk factor control, and therapeutic development.

Original languageEnglish (US)
Pages (from-to)1914-1919
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume35
Issue number9
DOIs
StatePublished - Sep 28 2015

Keywords

  • cardiovascular
  • histone deacetylases
  • inflammation
  • metabolic disease
  • sirtuins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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