Histopathological study of human TMJ perforated discs with emphasis on synovial membrane response

Emad S. Helmy, Robert A. Bays, Mohamed M.H. Sharawy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Fifteen perforated TMJ discs from human cadavers were studied histologically to examine the synovial membranes and to compare the findings with previous experimental results in monkeys. There were four with perforations in the bilaminar zone (these four discs were displaced anteriorly), three in the medial third of the disc, and eight in the lateral third of the disc. Histopathologically, there was an increase in vascularity and strong methyl pyronine-positive cellularity around the margins of the perforations. A young, loose, collagenous tissue lined the lateral margins of the perforated discs. Increased fibrous tissue content of the synovial subintimal territorial matrix and osteochondroid metaplasia were also seen. Severe synovial hyperplasia was visible in all joint recesses, but was greatest within those associated with displaced discs. There was patchy distribution of acidic glycoproteins, especially in the lateral parts of the perforated discs. As in the animal studies, human TMJ disc perforation was associated with a vigorous synovial reaction that was seen to form lateral bridges along the margins.

Original languageEnglish (US)
Pages (from-to)1048-1052
Number of pages5
JournalJournal of Oral and Maxillofacial Surgery
Volume47
Issue number10
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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