History of gestational diabetes, insulin resistance and coronary risk

Catherine Lucy Davis, Miriam Gutt, Maria M. Llabre, Jennifer B. Marks, Mary J. O'Sullivan, Jonell E. Potter, Julie L. Landel, Mahendra Kumar, Neil Schneiderman, Marc Gellman, Jay S. Skyler

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The purpose of this study was to examine characteristics associated with the insulin metabolic syndrome, including insulin resistance, abnormal glucose tolerance, dyslipidemia, obesity, and elevated blood pressure, among women who have experienced gestational diabetes. 39 nondiabetic, young (20-42 years), postpartum (3-18 months) white women were recruited from obstetrical clinics. Twenty-one women had a history of gestational diabetes; 18 had uncomplicated pregnancies. Multivariate analyses revealed a significant difference between groups in insulin resistance (M, measured by euglycemic clamp) and insulin levels (from an oral glucose tolerance test), with insulin resistance showing a statistically stronger difference than insulin levels. Groups also differed significantly when compared on a set of variables associated with insulin metabolic syndrome: glucose tolerance, triglycerides, blood pressure, and body-mass index. Using insulin resistance as a covariate eliminated these group differences, suggesting that insulin resistance is the key factor underlying insulin metabolic syndrome. The higher risk of later developing type 2 diabetes and hypertension in women who have a history of gestational diabetes is explicable by their poorer profile on variables associated with insulin metabolic syndrome, and appears to be attributable to insulin resistance. Thus, insulin resistance appears to distinguish young women at risk for cardiovascular disease. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalJournal of Diabetes and its Complications
Volume13
Issue number4
DOIs
StatePublished - Jul 1 1999

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Gestational Diabetes
Insulin Resistance
Insulin
Blood Pressure
Glucose
Glucose Clamp Technique
Glucose Tolerance Test
Dyslipidemias
Type 2 Diabetes Mellitus
Postpartum Period
Triglycerides
Body Mass Index
Cardiovascular Diseases
Multivariate Analysis
Obesity
Hypertension
Pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Davis, C. L., Gutt, M., Llabre, M. M., Marks, J. B., O'Sullivan, M. J., Potter, J. E., ... Skyler, J. S. (1999). History of gestational diabetes, insulin resistance and coronary risk. Journal of Diabetes and its Complications, 13(4), 216-223. https://doi.org/10.1016/S1056-8727(99)00048-3

History of gestational diabetes, insulin resistance and coronary risk. / Davis, Catherine Lucy; Gutt, Miriam; Llabre, Maria M.; Marks, Jennifer B.; O'Sullivan, Mary J.; Potter, Jonell E.; Landel, Julie L.; Kumar, Mahendra; Schneiderman, Neil; Gellman, Marc; Skyler, Jay S.

In: Journal of Diabetes and its Complications, Vol. 13, No. 4, 01.07.1999, p. 216-223.

Research output: Contribution to journalArticle

Davis, CL, Gutt, M, Llabre, MM, Marks, JB, O'Sullivan, MJ, Potter, JE, Landel, JL, Kumar, M, Schneiderman, N, Gellman, M & Skyler, JS 1999, 'History of gestational diabetes, insulin resistance and coronary risk', Journal of Diabetes and its Complications, vol. 13, no. 4, pp. 216-223. https://doi.org/10.1016/S1056-8727(99)00048-3
Davis, Catherine Lucy ; Gutt, Miriam ; Llabre, Maria M. ; Marks, Jennifer B. ; O'Sullivan, Mary J. ; Potter, Jonell E. ; Landel, Julie L. ; Kumar, Mahendra ; Schneiderman, Neil ; Gellman, Marc ; Skyler, Jay S. / History of gestational diabetes, insulin resistance and coronary risk. In: Journal of Diabetes and its Complications. 1999 ; Vol. 13, No. 4. pp. 216-223.
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