TY - JOUR
T1 - HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil
AU - Cortes, Eduardo
AU - Detels, Roger
AU - Aboulafia, David
AU - li, Xi Ling
AU - Moudgil, Tarsem
AU - Alam, Masud
AU - Bonecker, Carlos
AU - Gonzaga, Augusto
AU - Oyafuso, Luiza
AU - Tondo, Michele
AU - Boite, Carlos
AU - Hammershlak, Nelson
AU - Capitani, Carlos
AU - Slamon, Dennis J.
AU - ho, David D.
PY - 1989/4/13
Y1 - 1989/4/13
N2 - We conducted a serologic survey for antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and human T-cell lymphotropic virus Type I (HTLV-I) in 704 Brazilians with the acquired immunodeficiency syndrome (AIDS) or at risk for it. The study population included 70 homosexual men (11 of whom were prostitutes), 58 bisexual men (19 of whom were prostitutes), 101 female prostitutes from three socioeconomic groups, 13 wives of men with hemophilia who were seropositive for HIV-1 antibodies, and 47 blood donors with positive Venereal Disease Research Laboratory tests for syphilis, all from Rio de Janeiro; 86 female prostitutes from two rural towns in Minas Gerais; 133 patients with AIDS from São Paulo; and 196 men with bleeding disorders who were seropositive for HIV-1 antibodies on enzyme-linked immunosorbent assay, from São Paulo and Rio de Janeiro. The prevalence of HIV-1 infection was highest in the homosexual male prostitutes (45 percent), the wives of patients with hemophilia (38 percent), the bisexual men (28 percent), the homosexual men who were not prostitutes (19 percent), and the female prostitutes from the lower class (9 percent). Combined HIV-1 and HIV-2 infection was found in 3 percent of the patients with AIDS and in 1 percent of the homosexual men. The prevalence of HTLV-I infection ranged from 1 percent in rural female prostitutes to 13 percent in HIV-1–positive men with bleeding disorders in Rio de Janeiro. Combined HIV-1 and HTLV-I infection occurred in 1 to 11 percent of some male subgroups. We conclude that in Brazil HIV-1 infection is already well established among homosexuals, bisexuals, and lower-class female prostitutes, with bisexual men probably acting as a bridge between the heterosexual and homosexual communities, that HTLV-I infection is prevalent in groups at risk for AIDS, and that HIV-2 infection has already been introduced into the country. TWO major groups of human retroviruses, each with two subtypes, have been isolated: the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), and the human T-cell lymphotropic virus Types I and II (HTLV-I and HTLV-II).1 2 3 4 5 6 HIV-1 and HIV-2 are etiologic agents of the acquired immunodeficiency syndrome (AIDS). HIV-1 is present on all continents, but HIV-2 is found mainly in West Africa, with a few instances in which it has been isolated in Europe and one in an African woman living in the United States.7 8 9 10 To date, HIV-2 has not been isolated in natives of the Western Hemisphere. HTLV-I…
AB - We conducted a serologic survey for antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and human T-cell lymphotropic virus Type I (HTLV-I) in 704 Brazilians with the acquired immunodeficiency syndrome (AIDS) or at risk for it. The study population included 70 homosexual men (11 of whom were prostitutes), 58 bisexual men (19 of whom were prostitutes), 101 female prostitutes from three socioeconomic groups, 13 wives of men with hemophilia who were seropositive for HIV-1 antibodies, and 47 blood donors with positive Venereal Disease Research Laboratory tests for syphilis, all from Rio de Janeiro; 86 female prostitutes from two rural towns in Minas Gerais; 133 patients with AIDS from São Paulo; and 196 men with bleeding disorders who were seropositive for HIV-1 antibodies on enzyme-linked immunosorbent assay, from São Paulo and Rio de Janeiro. The prevalence of HIV-1 infection was highest in the homosexual male prostitutes (45 percent), the wives of patients with hemophilia (38 percent), the bisexual men (28 percent), the homosexual men who were not prostitutes (19 percent), and the female prostitutes from the lower class (9 percent). Combined HIV-1 and HIV-2 infection was found in 3 percent of the patients with AIDS and in 1 percent of the homosexual men. The prevalence of HTLV-I infection ranged from 1 percent in rural female prostitutes to 13 percent in HIV-1–positive men with bleeding disorders in Rio de Janeiro. Combined HIV-1 and HTLV-I infection occurred in 1 to 11 percent of some male subgroups. We conclude that in Brazil HIV-1 infection is already well established among homosexuals, bisexuals, and lower-class female prostitutes, with bisexual men probably acting as a bridge between the heterosexual and homosexual communities, that HTLV-I infection is prevalent in groups at risk for AIDS, and that HIV-2 infection has already been introduced into the country. TWO major groups of human retroviruses, each with two subtypes, have been isolated: the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), and the human T-cell lymphotropic virus Types I and II (HTLV-I and HTLV-II).1 2 3 4 5 6 HIV-1 and HIV-2 are etiologic agents of the acquired immunodeficiency syndrome (AIDS). HIV-1 is present on all continents, but HIV-2 is found mainly in West Africa, with a few instances in which it has been isolated in Europe and one in an African woman living in the United States.7 8 9 10 To date, HIV-2 has not been isolated in natives of the Western Hemisphere. HTLV-I…
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U2 - 10.1056/NEJM198904133201501
DO - 10.1056/NEJM198904133201501
M3 - Article
C2 - 2927478
AN - SCOPUS:0024522042
SN - 0028-4793
VL - 320
SP - 953
EP - 958
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 15
ER -