HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil

Eduardo Cortes, Roger Detels, David Aboulafia, Xi Ling li, Tarsem Moudgil, Masud Alam, Carlos Bonecker, Augusto Gonzaga, Luiza Oyafuso, Michele Tondo, Carlos Boite, Nelson Hammershlak, Carlos Capitani, Dennis J. Slamon, David D. ho

Research output: Contribution to journalArticle

Abstract

We conducted a serologic survey for antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and human T-cell lymphotropic virus Type I (HTLV-I) in 704 Brazilians with the acquired immunodeficiency syndrome (AIDS) or at risk for it. The study population included 70 homosexual men (11 of whom were prostitutes), 58 bisexual men (19 of whom were prostitutes), 101 female prostitutes from three socioeconomic groups, 13 wives of men with hemophilia who were seropositive for HIV-1 antibodies, and 47 blood donors with positive Venereal Disease Research Laboratory tests for syphilis, all from Rio de Janeiro; 86 female prostitutes from two rural towns in Minas Gerais; 133 patients with AIDS from São Paulo; and 196 men with bleeding disorders who were seropositive for HIV-1 antibodies on enzyme-linked immunosorbent assay, from São Paulo and Rio de Janeiro. The prevalence of HIV-1 infection was highest in the homosexual male prostitutes (45 percent), the wives of patients with hemophilia (38 percent), the bisexual men (28 percent), the homosexual men who were not prostitutes (19 percent), and the female prostitutes from the lower class (9 percent). Combined HIV-1 and HIV-2 infection was found in 3 percent of the patients with AIDS and in 1 percent of the homosexual men. The prevalence of HTLV-I infection ranged from 1 percent in rural female prostitutes to 13 percent in HIV-1–positive men with bleeding disorders in Rio de Janeiro. Combined HIV-1 and HTLV-I infection occurred in 1 to 11 percent of some male subgroups. We conclude that in Brazil HIV-1 infection is already well established among homosexuals, bisexuals, and lower-class female prostitutes, with bisexual men probably acting as a bridge between the heterosexual and homosexual communities, that HTLV-I infection is prevalent in groups at risk for AIDS, and that HIV-2 infection has already been introduced into the country. TWO major groups of human retroviruses, each with two subtypes, have been isolated: the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), and the human T-cell lymphotropic virus Types I and II (HTLV-I and HTLV-II).1 2 3 4 5 6 HIV-1 and HIV-2 are etiologic agents of the acquired immunodeficiency syndrome (AIDS). HIV-1 is present on all continents, but HIV-2 is found mainly in West Africa, with a few instances in which it has been isolated in Europe and one in an African woman living in the United States.7 8 9 10 To date, HIV-2 has not been isolated in natives of the Western Hemisphere. HTLV-I…

Original languageEnglish (US)
Pages (from-to)953-958
Number of pages6
JournalNew England Journal of Medicine
Volume320
Issue number15
DOIs
StatePublished - Apr 13 1989
Externally publishedYes

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HIV-2
Sex Workers
Brazil
HIV-1
Viruses
T-Lymphocytes
Infection
Acquired Immunodeficiency Syndrome
HIV Infections
Human T-lymphotropic virus 2
HIV Antibodies
Hemophilia A
Spouses
Sexual Minorities
Hemorrhage
Western Africa
Heterosexuality
Retroviridae
Syphilis
Sexually Transmitted Diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cortes, E., Detels, R., Aboulafia, D., li, X. L., Moudgil, T., Alam, M., ... ho, D. D. (1989). HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil. New England Journal of Medicine, 320(15), 953-958. https://doi.org/10.1056/NEJM198904133201501

HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil. / Cortes, Eduardo; Detels, Roger; Aboulafia, David; li, Xi Ling; Moudgil, Tarsem; Alam, Masud; Bonecker, Carlos; Gonzaga, Augusto; Oyafuso, Luiza; Tondo, Michele; Boite, Carlos; Hammershlak, Nelson; Capitani, Carlos; Slamon, Dennis J.; ho, David D.

In: New England Journal of Medicine, Vol. 320, No. 15, 13.04.1989, p. 953-958.

Research output: Contribution to journalArticle

Cortes, E, Detels, R, Aboulafia, D, li, XL, Moudgil, T, Alam, M, Bonecker, C, Gonzaga, A, Oyafuso, L, Tondo, M, Boite, C, Hammershlak, N, Capitani, C, Slamon, DJ & ho, DD 1989, 'HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil', New England Journal of Medicine, vol. 320, no. 15, pp. 953-958. https://doi.org/10.1056/NEJM198904133201501
Cortes, Eduardo ; Detels, Roger ; Aboulafia, David ; li, Xi Ling ; Moudgil, Tarsem ; Alam, Masud ; Bonecker, Carlos ; Gonzaga, Augusto ; Oyafuso, Luiza ; Tondo, Michele ; Boite, Carlos ; Hammershlak, Nelson ; Capitani, Carlos ; Slamon, Dennis J. ; ho, David D. / HIV-1, HIV-2, and HTLV-I Infection in High-Risk Groups in Brazil. In: New England Journal of Medicine. 1989 ; Vol. 320, No. 15. pp. 953-958.
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