HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women

Research output: Contribution to journalReview articlepeer-review

Abstract

Thanks to the advent of combination antiretroviral therapy (cART), people living with human immunodeficiency virus (HIV) (PLWH) experienced a marked increase in life expectancy but are now at higher risk for cardiovascular disease (CVD), the current leading cause of death in PLWH on cART. Although HIV preponderantly affects men over women, manifestations of HIV-related CVD differ by sex with women experiencing greater risks than men. Despite extensive investigation, the etiopathology of CVD, notably the respective contribution of viral infection and cART, remain ill-defined. However, both viral infection and cART have been reported to contribute to endothelial dysfunction, the precursor and major cause of atherosclerosis-associated CVD, through mechanisms involving endothelial cell activation, inflammation, and oxidative stress, all leading to reduced nitric oxide bioavailability. Therefore, preserving endothelial function in PLWH on cART should be a main target to reduce CVD morbidity and mortality, notably in females.

Original languageEnglish (US)
Pages (from-to)410-421
Number of pages12
JournalJACC: Basic to Translational Science
Volume7
Issue number4
DOIs
StatePublished - Apr 2022
Externally publishedYes

Keywords

  • combination antiretroviral therapy
  • endothelial dysfunction
  • HIV
  • sex differences

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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