HLA-A2 reactive antibodies in a patient who types as HLA-A2: The importance of high resolution typing and epitope-based antibody analysis

A. B. Hahn, Valia Bravo-Egana, J. L. Jackstadt, D. J. Conti, R. J. Duquesnoy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This report describes a case of a highly sensitized patient who had serum antibodies reacting with HLA-A2 but whose phenotype included HLA-A2. The determination of HLA mismatch acceptability at the antigen level was problematic, but high-resolution HLA typing information and epitope-based antibody specificity analysis based on the nonself-self paradigm of HLA epitope immunogenicity have provided a solution. This case supports the concept that HLA typing at the allele level offers a better approach to identifying suitable donors for sensitized patients.

Original languageEnglish (US)
Number of pages1
JournalTransplant Immunology
Volume32
Issue number3
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

HLA-A2 Antigen
Histocompatibility Testing
Epitopes
Antibody Specificity
Antibodies
Alleles
Tissue Donors
Phenotype
Antigens
Serum

Keywords

  • Antibody analysis
  • Epitope
  • HLA

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Transplantation

Cite this

HLA-A2 reactive antibodies in a patient who types as HLA-A2 : The importance of high resolution typing and epitope-based antibody analysis. / Hahn, A. B.; Bravo-Egana, Valia; Jackstadt, J. L.; Conti, D. J.; Duquesnoy, R. J.

In: Transplant Immunology, Vol. 32, No. 3, 01.06.2015.

Research output: Contribution to journalArticle

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