HLA-G and humanized mouse models as a novel therapeutic approach in transplantation

Ashwin Ajith, Vera Portik-Dobos, Daniel D. Horuzsko, Rajan Kapoor, Laura L. Mulloy, Anatolij Horuzsko

Research output: Contribution to journalReview articlepeer-review

Abstract

HLA-G is a nonclassical MHC-Class I molecule whose expression, along the feto-maternal barrier contributes towards tolerance of the semiallogeneic fetus during pregnancy. In light of its inhibitory properties, recent research has established HLA-G involvement in mechanisms responsible for directing allogeneic immune responses towards tolerance during allogeneic situations such as organ transplantation. Here, we critically review the data supporting the tolerogenic role of HLA-G in organ transplantation, the various factors influencing its expression, and the introduction of novel humanized mouse models that are one of the best approaches to assess the utility of HLA-G as a therapeutic tool in organ transplantation.

Original languageEnglish (US)
Pages (from-to)178-185
Number of pages8
JournalHuman Immunology
Volume81
Issue number4
DOIs
StatePublished - Apr 2020

Keywords

  • HLA-G
  • Humanized mouse model
  • Rejection
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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