HLA-G dimers in the prolongation of kidney allograft survival

Maureen Ezeakile, Vera Portik-Dobos, Juan Wu, Daniel D. Horuzsko, Rajan Kapoor, Muralidharan Jagadeesan, Laura L Mulloy, Anatolij Horuzsko

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12 Citations (Scopus)

Abstract

Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rejection of allogeneic tissue/organ. Current models of the interactions of HLA-G and its specific receptors explain it as functioning in a monomeric form. However, in recent years, new data has revealed the ability of HLA-G to form disulfide-linked dimeric complexes with high preferential binding and functional activities. Limited data are available on the role of soluble HLA-G dimers in clinical pathological conditions. We describe here the presence of soluble HLA-G dimers in kidney transplant patients. Our study showed that a high level of HLA-G dimers in plasma and increased expression of the membrane-bound form of HLA-G on monocytes are associated with prolongation of kidney allograft survival. We also determined that the presence of soluble HLA-G dimers links to the lower levels of proinflammatory cytokines, suggesting a potential role of HLA-G dimers in controlling the accompanying inflammatory state.

Original languageEnglish (US)
Article number153981
JournalJournal of Immunology Research
Volume2014
DOIs
StatePublished - Jan 1 2014

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HLA Antigens
Allografts
Kidney
Tissue Transplantation
Organ Transplantation
Disulfides
Monocytes
Protein Isoforms
Cytokines
Transplants
Membranes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

HLA-G dimers in the prolongation of kidney allograft survival. / Ezeakile, Maureen; Portik-Dobos, Vera; Wu, Juan; Horuzsko, Daniel D.; Kapoor, Rajan; Jagadeesan, Muralidharan; Mulloy, Laura L; Horuzsko, Anatolij.

In: Journal of Immunology Research, Vol. 2014, 153981, 01.01.2014.

Research output: Contribution to journalArticle

Ezeakile, Maureen ; Portik-Dobos, Vera ; Wu, Juan ; Horuzsko, Daniel D. ; Kapoor, Rajan ; Jagadeesan, Muralidharan ; Mulloy, Laura L ; Horuzsko, Anatolij. / HLA-G dimers in the prolongation of kidney allograft survival. In: Journal of Immunology Research. 2014 ; Vol. 2014.
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