HLA-G transgenic mice

Andrew Mellor, Min Zhou, Simon J. Conway, David Munn

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells. In addition, we have shown that trophoblast cells expressing H-2Kb under the control of HLA-G promoter elements affect maternal T cell phenotype and responsiveness during pregnancy. Using these same HLA-G/H-2Kb transgenic mice we have shown that trophoblast cells, expressing an inducible enzyme that degrades tryptophan, protects allogeneic conceptus expressing paternally-inherited transgenes from attack by maternal T cells that leads to fetal rejection. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalJournal of Reproductive Immunology
Volume43
Issue number2
DOIs
StatePublished - Jul 1 1999

Keywords

  • HLA-G
  • Mice
  • Pregnancy
  • Transgenic

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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