Hollow mesoporous zirconia delivery system for biomineralization precursors

Xue qing Huang, Hong ye Yang, Tao Luo, Cui Huang, Franklin Chi Meng Tay, Li na Niu

Research output: Contribution to journalArticle

Abstract

Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility. The PAH-ACP released from loaded hmZrO2 still retained the ability to infiltrate and mineralize collagen fibrils as well as exhibited osteoinductivity. A collagen scaffold blended with PAH-ACP@hmZrO2 supplement and stem cells may be a promising tool for bone tissue engineering. Statement of Significance: The advent of nanotechnology has catalyzed the development of bone tissue engineering strategies based on the combination of nanocarrier delivery systems and scaffolds, which provide distinct advantages, including the possibilities of sustained release and protection of the bioactive agents, site-specific pharmacological effects and reduction of side effects. Herein, hollow mesoporous zirconia (hmZrO2) nanocapsules with pH-sensitive capacity were synthesized for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of ACP (PAH-ACP). The loaded nanocapsules show good biocompatibility and demonstrate bioactivities for collagen biomineralization and bone marrow stromal cells osteoinduction. Our results may offer a promising tool for designing bone tissue engineering “cocktail therapy” involving seeding scaffolds with biomineralization precursors loaded hmZrO2 supplement and stem cells.

Original languageEnglish (US)
Pages (from-to)366-377
Number of pages12
JournalActa biomaterialia
Volume67
DOIs
StatePublished - Feb 1 2018

Fingerprint

Nanocapsules
Biomineralization
Tissue Engineering
Zirconia
Bone
Collagen
Calcium phosphate
Scaffolds (biology)
Tissue engineering
Bone and Bones
Polyamines
Mesenchymal Stromal Cells
Stem Cells
Tissue Scaffolds
Stem cells
Biocompatibility
Scaffolds
Biomimetics
Nanotechnology
Dental Implants

Keywords

  • Biomineralization
  • Nanocapsules
  • Osteoinduction
  • Tissue engineering
  • Zirconia

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Hollow mesoporous zirconia delivery system for biomineralization precursors. / Huang, Xue qing; Yang, Hong ye; Luo, Tao; Huang, Cui; Tay, Franklin Chi Meng; Niu, Li na.

In: Acta biomaterialia, Vol. 67, 01.02.2018, p. 366-377.

Research output: Contribution to journalArticle

Huang, Xue qing ; Yang, Hong ye ; Luo, Tao ; Huang, Cui ; Tay, Franklin Chi Meng ; Niu, Li na. / Hollow mesoporous zirconia delivery system for biomineralization precursors. In: Acta biomaterialia. 2018 ; Vol. 67. pp. 366-377.
@article{183932a435aa4633a423cfa45b96523b,
title = "Hollow mesoporous zirconia delivery system for biomineralization precursors",
abstract = "Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility. The PAH-ACP released from loaded hmZrO2 still retained the ability to infiltrate and mineralize collagen fibrils as well as exhibited osteoinductivity. A collagen scaffold blended with PAH-ACP@hmZrO2 supplement and stem cells may be a promising tool for bone tissue engineering. Statement of Significance: The advent of nanotechnology has catalyzed the development of bone tissue engineering strategies based on the combination of nanocarrier delivery systems and scaffolds, which provide distinct advantages, including the possibilities of sustained release and protection of the bioactive agents, site-specific pharmacological effects and reduction of side effects. Herein, hollow mesoporous zirconia (hmZrO2) nanocapsules with pH-sensitive capacity were synthesized for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of ACP (PAH-ACP). The loaded nanocapsules show good biocompatibility and demonstrate bioactivities for collagen biomineralization and bone marrow stromal cells osteoinduction. Our results may offer a promising tool for designing bone tissue engineering “cocktail therapy” involving seeding scaffolds with biomineralization precursors loaded hmZrO2 supplement and stem cells.",
keywords = "Biomineralization, Nanocapsules, Osteoinduction, Tissue engineering, Zirconia",
author = "Huang, {Xue qing} and Yang, {Hong ye} and Tao Luo and Cui Huang and Tay, {Franklin Chi Meng} and Niu, {Li na}",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.actbio.2017.11.049",
language = "English (US)",
volume = "67",
pages = "366--377",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Hollow mesoporous zirconia delivery system for biomineralization precursors

AU - Huang, Xue qing

AU - Yang, Hong ye

AU - Luo, Tao

AU - Huang, Cui

AU - Tay, Franklin Chi Meng

AU - Niu, Li na

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility. The PAH-ACP released from loaded hmZrO2 still retained the ability to infiltrate and mineralize collagen fibrils as well as exhibited osteoinductivity. A collagen scaffold blended with PAH-ACP@hmZrO2 supplement and stem cells may be a promising tool for bone tissue engineering. Statement of Significance: The advent of nanotechnology has catalyzed the development of bone tissue engineering strategies based on the combination of nanocarrier delivery systems and scaffolds, which provide distinct advantages, including the possibilities of sustained release and protection of the bioactive agents, site-specific pharmacological effects and reduction of side effects. Herein, hollow mesoporous zirconia (hmZrO2) nanocapsules with pH-sensitive capacity were synthesized for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of ACP (PAH-ACP). The loaded nanocapsules show good biocompatibility and demonstrate bioactivities for collagen biomineralization and bone marrow stromal cells osteoinduction. Our results may offer a promising tool for designing bone tissue engineering “cocktail therapy” involving seeding scaffolds with biomineralization precursors loaded hmZrO2 supplement and stem cells.

AB - Strategies based on the combination of nanocarrier delivery systems and scaffolds provide bone tissue engineering scaffolds with multifunctional capability. Zirconia, a biocompatible ceramic commonly used in orthopedic and dental implants, was used to synthesize hollow mesoporous nanocapsules for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of amorphous calcium phosphate (PAH-ACP) for collagen biomineralization and bone marrow stromal cells osteoinduction. Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility. The PAH-ACP released from loaded hmZrO2 still retained the ability to infiltrate and mineralize collagen fibrils as well as exhibited osteoinductivity. A collagen scaffold blended with PAH-ACP@hmZrO2 supplement and stem cells may be a promising tool for bone tissue engineering. Statement of Significance: The advent of nanotechnology has catalyzed the development of bone tissue engineering strategies based on the combination of nanocarrier delivery systems and scaffolds, which provide distinct advantages, including the possibilities of sustained release and protection of the bioactive agents, site-specific pharmacological effects and reduction of side effects. Herein, hollow mesoporous zirconia (hmZrO2) nanocapsules with pH-sensitive capacity were synthesized for loading, storage and sustained release of a novel polyamine-stabilized liquid precursor phase of ACP (PAH-ACP). The loaded nanocapsules show good biocompatibility and demonstrate bioactivities for collagen biomineralization and bone marrow stromal cells osteoinduction. Our results may offer a promising tool for designing bone tissue engineering “cocktail therapy” involving seeding scaffolds with biomineralization precursors loaded hmZrO2 supplement and stem cells.

KW - Biomineralization

KW - Nanocapsules

KW - Osteoinduction

KW - Tissue engineering

KW - Zirconia

UR - http://www.scopus.com/inward/record.url?scp=85037596885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037596885&partnerID=8YFLogxK

U2 - 10.1016/j.actbio.2017.11.049

DO - 10.1016/j.actbio.2017.11.049

M3 - Article

VL - 67

SP - 366

EP - 377

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

ER -