Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation

Rania Hamad, Calpurnia Jayakumar, Punithavathi Ranganathan, Riyaz Mohamed, Mahmoud M.I. El-Hamamy, Amina A. Dessouki, Abdelazim Ibrahim, Ganesan Ramesh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cisplatin is a highly effective chemotherapeutic drug used to treat a wide variety of solid tumors. However, its use was limited due its dose-limiting toxicity to the kidney. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. Honey is a naturally occurring complex liquid and widely used in traditional Ayurvedic medicine to treat many illnesses. However, its effect on cisplatin nephrotoxicity is unknown. To determine the role of honey in cisplatin nephrotoxicity, animals were pretreated orally for a week and then cisplatin was administered. Honey feeding was continued for another 3 days. Our results show that animals with cisplatin-induced kidney dysfunction, as determined by increased serum creatinine, which received honey feeding had less kidney dysfunction. Improved kidney function was associated with better preservation of kidney morphology in honey-treated group as compared to the cisplatin alone-treated group. Interestingly, honey feeding significantly reduced cisplatin-induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. Western blot analysis shows that cisplatin-induced increase in phosphorylation of NFkB was completely suppressed with honey feeding. In conclusion, honey feeding protects the kidney against cisplatin nephrotoxicity through suppression of inflammation and NFkB activation.

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume42
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Honey
Cisplatin
Inflammation
Kidney
Ayurvedic Medicine
Traditional Medicine
Chemokines
Creatinine
Cell Death
Western Blotting
Epithelial Cells
Phosphorylation
Cytokines

Keywords

  • Acute kidney injury
  • Cisplatin
  • Honey
  • Inflammation
  • NFkB
  • Nephrotoxicity

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Hamad, R., Jayakumar, C., Ranganathan, P., Mohamed, R., El-Hamamy, M. M. I., Dessouki, A. A., ... Ramesh, G. (2015). Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation. Clinical and Experimental Pharmacology and Physiology, 42(8), 843-848. https://doi.org/10.1111/1440-1681.12433

Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation. / Hamad, Rania; Jayakumar, Calpurnia; Ranganathan, Punithavathi; Mohamed, Riyaz; El-Hamamy, Mahmoud M.I.; Dessouki, Amina A.; Ibrahim, Abdelazim; Ramesh, Ganesan.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 42, No. 8, 01.08.2015, p. 843-848.

Research output: Contribution to journalArticle

Hamad, R, Jayakumar, C, Ranganathan, P, Mohamed, R, El-Hamamy, MMI, Dessouki, AA, Ibrahim, A & Ramesh, G 2015, 'Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation', Clinical and Experimental Pharmacology and Physiology, vol. 42, no. 8, pp. 843-848. https://doi.org/10.1111/1440-1681.12433
Hamad, Rania ; Jayakumar, Calpurnia ; Ranganathan, Punithavathi ; Mohamed, Riyaz ; El-Hamamy, Mahmoud M.I. ; Dessouki, Amina A. ; Ibrahim, Abdelazim ; Ramesh, Ganesan. / Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation. In: Clinical and Experimental Pharmacology and Physiology. 2015 ; Vol. 42, No. 8. pp. 843-848.
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