Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

Xianhe Bai, Francesca Cerimele, Masuko Ushio-Fukai, Muhammad Waqas, Paul M. Campbell, Baskaran Govindarajan, Channing J. Der, Traci Battle, David A. Frank, Keqiang Ye, Emma Murad, Wolfgang Dubiel, Gerald Soff, Jack L. Arbiser

Research output: Contribution to journalArticle

290 Scopus citations

Abstract

Natural products comprise a major source of small molecular weight angiogenesis inhibitors. We have used the transformed endothelial cell line SVR as an effective screen of natural product extracts to isolate anti-angiogenesis and anti-tumor compounds. Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays. We found that the small molecular weight compound honokiol is the active principle of magnolia extract. Honokiol exhibited potent anti-proliferative activity against SVR cells in vitro. In addition, honokiol demonstrated preferential inhibition of primary human endothelial cells compared with fibroblasts and this inhibition was antagonized by antibodies against TNFα-related apoptosis-inducing ligand. In vivo, honokiol was highly effective against angiosarcoma in nude mice. Our preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.

Original languageEnglish (US)
Pages (from-to)35501-35507
Number of pages7
JournalJournal of Biological Chemistry
Volume278
Issue number37
DOIs
StatePublished - Sep 12 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Bai, X., Cerimele, F., Ushio-Fukai, M., Waqas, M., Campbell, P. M., Govindarajan, B., Der, C. J., Battle, T., Frank, D. A., Ye, K., Murad, E., Dubiel, W., Soff, G., & Arbiser, J. L. (2003). Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Journal of Biological Chemistry, 278(37), 35501-35507. https://doi.org/10.1074/jbc.M302967200