Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval

Volker Korz, Julietta Uta Frey

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Recently it was shown that holeboard training can reinforce, i.e., transform early-LTP into late-LTP in the dentate gyrus during the initial formation of a long-term spatial reference memory in rats. The consolidation of LTP as well as of the reference memory was dependent on protein synthesis. We have now investigated the transmitter systems involved in this reinforcement and found that LTP-consolidation and memory retrieval were dependent on β-adrenergic, dopaminergic, and mineralocorticoid receptor (MR) activation, whereas glucocorticoid receptors (GRs) were not involved. Blockade of the β-adrenergic signaling pathway significantly increased the number of reference memory errors compared with MR and dopamine receptor inhibition. In addition, β-adrenergic blockade impaired the working memory. Therefore, we suggest that β-adrenergic receptor activation is the main signaling system required for the retrieval of spatial memory. In addition, other modulatory interactions such as dopaminergic as well as MR systems are involved. This result points to specific roles of different modulatory systems during the retrieval of specific components of spatial memory. The data provide evidence for similar integrative interactions between different signaling systems during cellular memory processes.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalLearning and Memory
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2007

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Mineralocorticoid Receptors
Long-Term Memory
Long-Term Potentiation
Adrenergic Agents
Adrenergic Receptors
Glucocorticoid Receptors
Dentate Gyrus
Dopamine Receptors
Short-Term Memory
Reinforcement (Psychology)
Spatial Memory
Proteins

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Hormonal and monoamine signaling during reinforcement of hippocampal long-term potentiation and memory retrieval. / Korz, Volker; Frey, Julietta Uta.

In: Learning and Memory, Vol. 14, No. 3, 01.03.2007, p. 160-166.

Research output: Contribution to journalArticle

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