How to increase the durability of resin-dentin bonds.

David Henry Pashley, Franklin Chi Meng Tay, Satoshi Imazato

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Resin-dentin bonds are not as durable as was previously thought. Microtensile bond strengths often fall 30% to 40% in 6 to 12 months. The cause of this poor durability is a combination of the activation of matrix metalloproteinases (MMPs) by weak acids such as lactic acid released by caries-producing bacteria, and acid-etchants used in adhesive bonding systems. These acids uncover and activate matrix-bound MMPs. The other contributing factor is incomplete resin infiltration. If all exposed collagen fibrils were enveloped by resin, the MMPs would not have free access to water, an obligatory requirement of these enzymes. Recently, several inhibitors of MMPs have been added to adhesive primers. Examples include chlorhexidine (CHX), benzalkonium chloride (BAC), and MDPB, an antibacterial monomer used in a two-step self-etching primer adhesive. The advantage of MDPB over CHX and BAC is that it polymerizes with adhesive resins and cannot leach from the hybrid layer. This is an example of what can be termed a "therapeutic adhesive system" that provides anti-MMP activity along with antibacterial qualities.

Original languageEnglish (US)
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
Volume32
Issue number7
StatePublished - Sep 1 2011

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Dentin
Adhesives
Matrix Metalloproteinases
Benzalkonium Compounds
Chlorhexidine
Acids
Matrix Metalloproteinase Inhibitors
Lactic Acid
Collagen
Bacteria
Water
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

How to increase the durability of resin-dentin bonds. / Pashley, David Henry; Tay, Franklin Chi Meng; Imazato, Satoshi.

In: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), Vol. 32, No. 7, 01.09.2011.

Research output: Contribution to journalArticle

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