HPV as a model for the development of prophylactic and therapeutic cancer vaccines

Raed N. Samara, Samir N. Khleif

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.

Original languageEnglish (US)
Pages (from-to)766-773
Number of pages8
JournalCurrent Molecular Medicine
Volume9
Issue number6
DOIs
StatePublished - Aug 1 2009

Fingerprint

Cancer Vaccines
Vaccines
Viral Proteins
Public health
Therapeutics
Infection
Viruses
Public Health
Genes
Research Personnel
Genome
Mortality
Neoplasms
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

HPV as a model for the development of prophylactic and therapeutic cancer vaccines. / Samara, Raed N.; Khleif, Samir N.

In: Current Molecular Medicine, Vol. 9, No. 6, 01.08.2009, p. 766-773.

Research output: Contribution to journalReview article

Samara, Raed N. ; Khleif, Samir N. / HPV as a model for the development of prophylactic and therapeutic cancer vaccines. In: Current Molecular Medicine. 2009 ; Vol. 9, No. 6. pp. 766-773.
@article{81dbcc6b319b41d2b5401b790ba2d29b,
title = "HPV as a model for the development of prophylactic and therapeutic cancer vaccines",
abstract = "HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.",
author = "Samara, {Raed N.} and Khleif, {Samir N.}",
year = "2009",
month = "8",
day = "1",
doi = "10.2174/156652409788970625",
language = "English (US)",
volume = "9",
pages = "766--773",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - HPV as a model for the development of prophylactic and therapeutic cancer vaccines

AU - Samara, Raed N.

AU - Khleif, Samir N.

PY - 2009/8/1

Y1 - 2009/8/1

N2 - HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.

AB - HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.

UR - http://www.scopus.com/inward/record.url?scp=70350525547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350525547&partnerID=8YFLogxK

U2 - 10.2174/156652409788970625

DO - 10.2174/156652409788970625

M3 - Review article

VL - 9

SP - 766

EP - 773

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 6

ER -