HS signals through protein S-Sulfhydration

Asif K. Mustafa, Moataz M. Gadalla, Nilkantha Sen, Seyun Kim, Weitong Mu, Sadia K. Gazi, Roxanne K. Barrow, Guangdong Yang, Rui Wang, Solomon H. Snyder

Research output: Contribution to journalArticle

655 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine g-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. Wenow show that H2S physiologically modifies cysteines in a large number of proteins byS-sulfhydration.About 10 to 25% ofmany liver proteins, includingactin, tubulin, andglyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions. Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins.

Original languageEnglish (US)
Pages (from-to)ra72
JournalScience Signaling
Volume2
Issue number96
DOIs
StatePublished - Nov 10 2009

Fingerprint

Protein S
Cystathionine
Hydrogen Sulfide
Proteins
Lyases
Post Translational Protein Processing
Tubulin
Vasodilator Agents
Polymerization
Liver
Cysteine
Actins
Oxidoreductases
Phosphates
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Mustafa, A. K., Gadalla, M. M., Sen, N., Kim, S., Mu, W., Gazi, S. K., ... Snyder, S. H. (2009). HS signals through protein S-Sulfhydration. Science Signaling, 2(96), ra72. https://doi.org/10.1126/scisignal.2000464

HS signals through protein S-Sulfhydration. / Mustafa, Asif K.; Gadalla, Moataz M.; Sen, Nilkantha; Kim, Seyun; Mu, Weitong; Gazi, Sadia K.; Barrow, Roxanne K.; Yang, Guangdong; Wang, Rui; Snyder, Solomon H.

In: Science Signaling, Vol. 2, No. 96, 10.11.2009, p. ra72.

Research output: Contribution to journalArticle

Mustafa, AK, Gadalla, MM, Sen, N, Kim, S, Mu, W, Gazi, SK, Barrow, RK, Yang, G, Wang, R & Snyder, SH 2009, 'HS signals through protein S-Sulfhydration', Science Signaling, vol. 2, no. 96, pp. ra72. https://doi.org/10.1126/scisignal.2000464
Mustafa AK, Gadalla MM, Sen N, Kim S, Mu W, Gazi SK et al. HS signals through protein S-Sulfhydration. Science Signaling. 2009 Nov 10;2(96):ra72. https://doi.org/10.1126/scisignal.2000464
Mustafa, Asif K. ; Gadalla, Moataz M. ; Sen, Nilkantha ; Kim, Seyun ; Mu, Weitong ; Gazi, Sadia K. ; Barrow, Roxanne K. ; Yang, Guangdong ; Wang, Rui ; Snyder, Solomon H. / HS signals through protein S-Sulfhydration. In: Science Signaling. 2009 ; Vol. 2, No. 96. pp. ra72.
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