HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Somik Chatterjee, Jason W. Wang, Mary J. Cismowski, John R. Bower, Kenneth Steven Rosenthal

Research output: Contribution to journalArticle

1 Scopus citations


The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

Original languageEnglish (US)
Pages (from-to)661-663
Number of pages3
JournalArchives of Virology
Issue number4
StatePublished - Apr 1 2009
Externally publishedYes


ASJC Scopus subject areas

  • Virology

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