HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing

Somik Chatterjee, Jason W. Wang, Mary J. Cismowski, John R. Bower, Kenneth Steven Rosenthal

Research output: Contribution to journalArticle

Abstract

The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

Original languageEnglish (US)
Pages (from-to)661-663
Number of pages3
JournalArchives of Virology
Volume154
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

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Simplexvirus
Glycoproteins
Human Herpesvirus 1
Vero Cells
Human Herpesvirus 2
human herpesvirus-2 ICP34.5 protein
Infection
Genes

ASJC Scopus subject areas

  • Virology

Cite this

Chatterjee, S., Wang, J. W., Cismowski, M. J., Bower, J. R., & Rosenthal, K. S. (2009). HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. Archives of Virology, 154(4), 661-663. https://doi.org/10.1007/s00705-009-0341-9

HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. / Chatterjee, Somik; Wang, Jason W.; Cismowski, Mary J.; Bower, John R.; Rosenthal, Kenneth Steven.

In: Archives of Virology, Vol. 154, No. 4, 01.04.2009, p. 661-663.

Research output: Contribution to journalArticle

Chatterjee, S, Wang, JW, Cismowski, MJ, Bower, JR & Rosenthal, KS 2009, 'HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing', Archives of Virology, vol. 154, no. 4, pp. 661-663. https://doi.org/10.1007/s00705-009-0341-9
Chatterjee S, Wang JW, Cismowski MJ, Bower JR, Rosenthal KS. HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. Archives of Virology. 2009 Apr 1;154(4):661-663. https://doi.org/10.1007/s00705-009-0341-9
Chatterjee, Somik ; Wang, Jason W. ; Cismowski, Mary J. ; Bower, John R. ; Rosenthal, Kenneth Steven. / HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing. In: Archives of Virology. 2009 ; Vol. 154, No. 4. pp. 661-663.
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