HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal

Aniko Szabo, Josep Dalmau, Geoff Manley, Myrna Rosenfeld, Ellen Wong, John Henson, Jerome B. Posner, Henry M. Furneaux

Research output: Contribution to journalArticlepeer-review

497 Scopus citations

Abstract

A neuronal antigen (HuD) recognized by the sera of patients with antibody-assoclated paraneoplastic encephalomyelitis has been isolated by screening a λ cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalCell
Volume67
Issue number2
DOIs
StatePublished - Oct 18 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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