A neuronal antigen (HuD) recognized by the sera of patients with antibody-assoclated paraneoplastic encephalomyelitis has been isolated by screening a λ cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)