@article{a980a704eaa34d58a5795163eb2e828a,
title = "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal",
abstract = "A neuronal antigen (HuD) recognized by the sera of patients with antibody-assoclated paraneoplastic encephalomyelitis has been isolated by screening a λ cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.",
author = "Aniko Szabo and Josep Dalmau and Geoff Manley and Myrna Rosenfeld and Ellen Wong and John Henson and Posner, {Jerome B.} and Furneaux, {Henry M.}",
note = "Funding Information: We are grateful to M. Caudy for helpful discussion, to B. Darnell for careful reading of the manuscript, and to B. Nevins for his patience and diligence in preparing the manuscript. This work was supported by American Cancer Society grant PD-359 (H. M. F.) and National Institutes of Health grant NS-26064 (J. B. P.). G. M. is a medical scientist training program fellow. J. D. is supported by a grant from the Fundo de Investigaciones Sanitarias de la Seguridad Social (Spain). J. H. is supported in part by grant CA 095-12-06 from the National Cancer Institute. M. R. is a Charles A. Dana Foundation Fellow and is also supported in part by NtH grant CA-09512.",
year = "1991",
month = oct,
day = "18",
doi = "10.1016/0092-8674(91)90184-Z",
language = "English (US)",
volume = "67",
pages = "325--333",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}
