Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

Xavier Castellsagué, Kevin A. Ault, F. Xavier Bosch, Darron Brown, Jack Cuzick, Daron G. Ferris, Elmar A. Joura, Suzanne M. Garland, Anna R. Giuliano, Mauricio Hernandez-Avila, Warner Huh, Ole Erik Iversen, Susanne K. Kjaer, Joaquin Luna, Joseph Monsonego, Nubia Muñoz, Evan Myers, Jorma Paavonen, Punnee Pitisuttihum, Marc StebenCosette M. Wheeler, Gonzalo Perez, Alfred Saah, Alain Luxembourg, Heather L. Sings, Christine Velicer

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region. Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalPapillomavirus Research
Volume2
DOIs
StatePublished - Dec 1 2016

Keywords

  • Adenocarcinoma in situ
  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • Human papillomavirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Castellsagué, X., Ault, K. A., Bosch, F. X., Brown, D., Cuzick, J., Ferris, D. G., Joura, E. A., Garland, S. M., Giuliano, A. R., Hernandez-Avila, M., Huh, W., Iversen, O. E., Kjaer, S. K., Luna, J., Monsonego, J., Muñoz, N., Myers, E., Paavonen, J., Pitisuttihum, P., ... Velicer, C. (2016). Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region. Papillomavirus Research, 2, 61-69. https://doi.org/10.1016/j.pvr.2016.03.002