Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad

Glennis M. Andall-Brereton, Felicia Hosein, Rosa A. Salas, Wayne Mohammed, Michele A. Monteil, Vanessa Goleski, Alberto Severini, Sarah M.M. Quesnel, Christine V.F. Carrington, Laura Lee Boodram, Eldonna Boisson, Patrick E. Akpaka, Rosemarie C. Paul

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. Human papillomavirus (HPV) genotypes and their relative prevalences were determined in a cohort of 310 sexually active women in Trinidad, West Indies. Methods. Cervical samples were collected with Ayre's spatulas and endocervical brushes. Samples were used for the conventional Papanicolaou test and for determining HPV genotypes by amplification of a section of the viral L1 gene, followed by DNA sequencing and probe hybridization. Results. HPV infections were identified in 126 of 310 (40.6%) women. Of them, 83 (65.8%) were infected with high-risk HPV, 16 (12.7%) with low-risk HPV, and 27 (21.4%) with HPV types of unknown risk. HPV 52 (12.7%) was the most frequently occurring highrisk type, followed by HPV 66 (10.3%), HPV 16 (9.5%), and HPV 18 (8.6%). High-risk types HPV 16 and HPV 66 were each found in 3 (20.0%) and HPV 18 was found in 1 (6.6%) of the 15 women with abnormal cytology. Conclusions. Cervical HPV prevalence and heterogeneity of HPV genotypes are high in this Trinidad cohort. The relative importance of HPV genotypes in the development of cervical lesions needs further investigation in Trinidad in order to better understand the epidemiology of HPV infections as well as to determine the role of HPV testing in the screening, prevention, and control of cervical cancer. This pilot study provided important information on the prevalence of HPV genotypes, which will be used in future nationwide studies.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume29
Issue number4
StatePublished - Apr 1 2011

Fingerprint

Trinidad and Tobago
Genotype
Human papillomavirus 16
Human papillomavirus 18
Papillomavirus Infections
West Indies
Papanicolaou Test
Viral Genes
DNA Probes
DNA Sequence Analysis

Keywords

  • Caribbean
  • Cervix neoplasms
  • Papillomaviridae
  • Prevalence
  • Prevention
  • Trinidad and tobago

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Andall-Brereton, G. M., Hosein, F., Salas, R. A., Mohammed, W., Monteil, M. A., Goleski, V., ... Paul, R. C. (2011). Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad. Revista Panamericana de Salud Publica/Pan American Journal of Public Health, 29(4), 220-226.

Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad. / Andall-Brereton, Glennis M.; Hosein, Felicia; Salas, Rosa A.; Mohammed, Wayne; Monteil, Michele A.; Goleski, Vanessa; Severini, Alberto; Quesnel, Sarah M.M.; Carrington, Christine V.F.; Boodram, Laura Lee; Boisson, Eldonna; Akpaka, Patrick E.; Paul, Rosemarie C.

In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health, Vol. 29, No. 4, 01.04.2011, p. 220-226.

Research output: Contribution to journalArticle

Andall-Brereton, GM, Hosein, F, Salas, RA, Mohammed, W, Monteil, MA, Goleski, V, Severini, A, Quesnel, SMM, Carrington, CVF, Boodram, LL, Boisson, E, Akpaka, PE & Paul, RC 2011, 'Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad', Revista Panamericana de Salud Publica/Pan American Journal of Public Health, vol. 29, no. 4, pp. 220-226.
Andall-Brereton GM, Hosein F, Salas RA, Mohammed W, Monteil MA, Goleski V et al. Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad. Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2011 Apr 1;29(4):220-226.
Andall-Brereton, Glennis M. ; Hosein, Felicia ; Salas, Rosa A. ; Mohammed, Wayne ; Monteil, Michele A. ; Goleski, Vanessa ; Severini, Alberto ; Quesnel, Sarah M.M. ; Carrington, Christine V.F. ; Boodram, Laura Lee ; Boisson, Eldonna ; Akpaka, Patrick E. ; Paul, Rosemarie C. / Human papillomavirus genotypes and their prevalence in a cohort of women in Trinidad. In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2011 ; Vol. 29, No. 4. pp. 220-226.
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abstract = "Objective. Human papillomavirus (HPV) genotypes and their relative prevalences were determined in a cohort of 310 sexually active women in Trinidad, West Indies. Methods. Cervical samples were collected with Ayre's spatulas and endocervical brushes. Samples were used for the conventional Papanicolaou test and for determining HPV genotypes by amplification of a section of the viral L1 gene, followed by DNA sequencing and probe hybridization. Results. HPV infections were identified in 126 of 310 (40.6{\%}) women. Of them, 83 (65.8{\%}) were infected with high-risk HPV, 16 (12.7{\%}) with low-risk HPV, and 27 (21.4{\%}) with HPV types of unknown risk. HPV 52 (12.7{\%}) was the most frequently occurring highrisk type, followed by HPV 66 (10.3{\%}), HPV 16 (9.5{\%}), and HPV 18 (8.6{\%}). High-risk types HPV 16 and HPV 66 were each found in 3 (20.0{\%}) and HPV 18 was found in 1 (6.6{\%}) of the 15 women with abnormal cytology. Conclusions. Cervical HPV prevalence and heterogeneity of HPV genotypes are high in this Trinidad cohort. The relative importance of HPV genotypes in the development of cervical lesions needs further investigation in Trinidad in order to better understand the epidemiology of HPV infections as well as to determine the role of HPV testing in the screening, prevention, and control of cervical cancer. This pilot study provided important information on the prevalence of HPV genotypes, which will be used in future nationwide studies.",
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AU - Hosein, Felicia

AU - Salas, Rosa A.

AU - Mohammed, Wayne

AU - Monteil, Michele A.

AU - Goleski, Vanessa

AU - Severini, Alberto

AU - Quesnel, Sarah M.M.

AU - Carrington, Christine V.F.

AU - Boodram, Laura Lee

AU - Boisson, Eldonna

AU - Akpaka, Patrick E.

AU - Paul, Rosemarie C.

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N2 - Objective. Human papillomavirus (HPV) genotypes and their relative prevalences were determined in a cohort of 310 sexually active women in Trinidad, West Indies. Methods. Cervical samples were collected with Ayre's spatulas and endocervical brushes. Samples were used for the conventional Papanicolaou test and for determining HPV genotypes by amplification of a section of the viral L1 gene, followed by DNA sequencing and probe hybridization. Results. HPV infections were identified in 126 of 310 (40.6%) women. Of them, 83 (65.8%) were infected with high-risk HPV, 16 (12.7%) with low-risk HPV, and 27 (21.4%) with HPV types of unknown risk. HPV 52 (12.7%) was the most frequently occurring highrisk type, followed by HPV 66 (10.3%), HPV 16 (9.5%), and HPV 18 (8.6%). High-risk types HPV 16 and HPV 66 were each found in 3 (20.0%) and HPV 18 was found in 1 (6.6%) of the 15 women with abnormal cytology. Conclusions. Cervical HPV prevalence and heterogeneity of HPV genotypes are high in this Trinidad cohort. The relative importance of HPV genotypes in the development of cervical lesions needs further investigation in Trinidad in order to better understand the epidemiology of HPV infections as well as to determine the role of HPV testing in the screening, prevention, and control of cervical cancer. This pilot study provided important information on the prevalence of HPV genotypes, which will be used in future nationwide studies.

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