Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age

Suzanne M. Garland, Elmar A. Joura, Kevin A. Ault, F. Xavier Bosch, Darron R. Brown, Xavier Castellsagué, Alex Ferenczy, Daron Gale Ferris, Anna R. Giuliano, Mauricio Hernandez-Avila, Warner K. Huh, Ole Erik Iversen, Susanne K. Kjaer, Robert J. Kurman, Joaquin Luna, Joseph Monsonego, Nubia Muñoz, Jorma Paavonen, Punnee Pitisuttihum, Brigitte M. RonnettMarc Steben, Mark H. Stoler, Cosette M. Wheeler, Dorothy J. Wiley, Gonzalo Perez, Alfred J. Saah, Alain Luxembourg, Se Li, Mark J. DiNubile, Monika Wagner, Christine Velicer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods. RESULTS: During approximately 4 years of follow-up in 8,798 females, 40 vulvar LSILs and 46 vulvar HSILs were diagnosed in 68 females, and 118 vaginal LSILs and 33 vaginal HSILs were diagnosed in 107 females. Females developing vulvar (41.2%) or vaginal (49.5%) lesions also had cervical lesions, whereas 6.5% of females with cervical lesions had vaginal or vulvar lesions. At least 1 of the 14 HPV genotypes was detected in females with vulvar LSIL (72.5%), vulvar HSIL (91.3%), vaginal LSIL (61.9%), and vaginal HSIL (72.7%). Considering only HPV-positive lesions, the nine most common genotypes causing cervical cancer and anogenital warts (6, 11, 16, 18, 31, 33, 45, 52, and 58) were found in 89.4% of vulvar LSILs, 100% of vulvar HSILs, 56.0% of vaginal LSILs, and 78.3% of vaginal HSILs. CONCLUSION: Most vulvar and vaginal lesions were attributable to at least 1 of the 14 HPV genotypes analyzed. Effective immunization programs could potentially prevent substantial numbers of HPV-related vulvar and vaginal LSILs and HSILs.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalObstetrics and Gynecology
Volume132
Issue number2
DOIs
StatePublished - Jan 1 2018

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Genotype
Neoplasms
Warts
Uterine Cervical Neoplasms
Human papillomavirus 6
Papillomavirus Vaccines
Immunization Programs
Multiplex Polymerase Chain Reaction
Placebos

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Garland, S. M., Joura, E. A., Ault, K. A., Bosch, F. X., Brown, D. R., Castellsagué, X., ... Velicer, C. (2018). Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. Obstetrics and Gynecology, 132(2), 261-270. https://doi.org/10.1097/AOG.0000000000002736

Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. / Garland, Suzanne M.; Joura, Elmar A.; Ault, Kevin A.; Bosch, F. Xavier; Brown, Darron R.; Castellsagué, Xavier; Ferenczy, Alex; Ferris, Daron Gale; Giuliano, Anna R.; Hernandez-Avila, Mauricio; Huh, Warner K.; Iversen, Ole Erik; Kjaer, Susanne K.; Kurman, Robert J.; Luna, Joaquin; Monsonego, Joseph; Muñoz, Nubia; Paavonen, Jorma; Pitisuttihum, Punnee; Ronnett, Brigitte M.; Steben, Marc; Stoler, Mark H.; Wheeler, Cosette M.; Wiley, Dorothy J.; Perez, Gonzalo; Saah, Alfred J.; Luxembourg, Alain; Li, Se; DiNubile, Mark J.; Wagner, Monika; Velicer, Christine.

In: Obstetrics and Gynecology, Vol. 132, No. 2, 01.01.2018, p. 261-270.

Research output: Contribution to journalArticle

Garland, SM, Joura, EA, Ault, KA, Bosch, FX, Brown, DR, Castellsagué, X, Ferenczy, A, Ferris, DG, Giuliano, AR, Hernandez-Avila, M, Huh, WK, Iversen, OE, Kjaer, SK, Kurman, RJ, Luna, J, Monsonego, J, Muñoz, N, Paavonen, J, Pitisuttihum, P, Ronnett, BM, Steben, M, Stoler, MH, Wheeler, CM, Wiley, DJ, Perez, G, Saah, AJ, Luxembourg, A, Li, S, DiNubile, MJ, Wagner, M & Velicer, C 2018, 'Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age', Obstetrics and Gynecology, vol. 132, no. 2, pp. 261-270. https://doi.org/10.1097/AOG.0000000000002736
Garland, Suzanne M. ; Joura, Elmar A. ; Ault, Kevin A. ; Bosch, F. Xavier ; Brown, Darron R. ; Castellsagué, Xavier ; Ferenczy, Alex ; Ferris, Daron Gale ; Giuliano, Anna R. ; Hernandez-Avila, Mauricio ; Huh, Warner K. ; Iversen, Ole Erik ; Kjaer, Susanne K. ; Kurman, Robert J. ; Luna, Joaquin ; Monsonego, Joseph ; Muñoz, Nubia ; Paavonen, Jorma ; Pitisuttihum, Punnee ; Ronnett, Brigitte M. ; Steben, Marc ; Stoler, Mark H. ; Wheeler, Cosette M. ; Wiley, Dorothy J. ; Perez, Gonzalo ; Saah, Alfred J. ; Luxembourg, Alain ; Li, Se ; DiNubile, Mark J. ; Wagner, Monika ; Velicer, Christine. / Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. In: Obstetrics and Gynecology. 2018 ; Vol. 132, No. 2. pp. 261-270.
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title = "Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age",
abstract = "OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods. RESULTS: During approximately 4 years of follow-up in 8,798 females, 40 vulvar LSILs and 46 vulvar HSILs were diagnosed in 68 females, and 118 vaginal LSILs and 33 vaginal HSILs were diagnosed in 107 females. Females developing vulvar (41.2{\%}) or vaginal (49.5{\%}) lesions also had cervical lesions, whereas 6.5{\%} of females with cervical lesions had vaginal or vulvar lesions. At least 1 of the 14 HPV genotypes was detected in females with vulvar LSIL (72.5{\%}), vulvar HSIL (91.3{\%}), vaginal LSIL (61.9{\%}), and vaginal HSIL (72.7{\%}). Considering only HPV-positive lesions, the nine most common genotypes causing cervical cancer and anogenital warts (6, 11, 16, 18, 31, 33, 45, 52, and 58) were found in 89.4{\%} of vulvar LSILs, 100{\%} of vulvar HSILs, 56.0{\%} of vaginal LSILs, and 78.3{\%} of vaginal HSILs. CONCLUSION: Most vulvar and vaginal lesions were attributable to at least 1 of the 14 HPV genotypes analyzed. Effective immunization programs could potentially prevent substantial numbers of HPV-related vulvar and vaginal LSILs and HSILs.",
author = "Garland, {Suzanne M.} and Joura, {Elmar A.} and Ault, {Kevin A.} and Bosch, {F. Xavier} and Brown, {Darron R.} and Xavier Castellsagu{\'e} and Alex Ferenczy and Ferris, {Daron Gale} and Giuliano, {Anna R.} and Mauricio Hernandez-Avila and Huh, {Warner K.} and Iversen, {Ole Erik} and Kjaer, {Susanne K.} and Kurman, {Robert J.} and Joaquin Luna and Joseph Monsonego and Nubia Mu{\~n}oz and Jorma Paavonen and Punnee Pitisuttihum and Ronnett, {Brigitte M.} and Marc Steben and Stoler, {Mark H.} and Wheeler, {Cosette M.} and Wiley, {Dorothy J.} and Gonzalo Perez and Saah, {Alfred J.} and Alain Luxembourg and Se Li and DiNubile, {Mark J.} and Monika Wagner and Christine Velicer",
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TY - JOUR

T1 - Human Papillomavirus Genotypes from Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age

AU - Garland, Suzanne M.

AU - Joura, Elmar A.

AU - Ault, Kevin A.

AU - Bosch, F. Xavier

AU - Brown, Darron R.

AU - Castellsagué, Xavier

AU - Ferenczy, Alex

AU - Ferris, Daron Gale

AU - Giuliano, Anna R.

AU - Hernandez-Avila, Mauricio

AU - Huh, Warner K.

AU - Iversen, Ole Erik

AU - Kjaer, Susanne K.

AU - Kurman, Robert J.

AU - Luna, Joaquin

AU - Monsonego, Joseph

AU - Muñoz, Nubia

AU - Paavonen, Jorma

AU - Pitisuttihum, Punnee

AU - Ronnett, Brigitte M.

AU - Steben, Marc

AU - Stoler, Mark H.

AU - Wheeler, Cosette M.

AU - Wiley, Dorothy J.

AU - Perez, Gonzalo

AU - Saah, Alfred J.

AU - Luxembourg, Alain

AU - Li, Se

AU - DiNubile, Mark J.

AU - Wagner, Monika

AU - Velicer, Christine

PY - 2018/1/1

Y1 - 2018/1/1

N2 - OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods. RESULTS: During approximately 4 years of follow-up in 8,798 females, 40 vulvar LSILs and 46 vulvar HSILs were diagnosed in 68 females, and 118 vaginal LSILs and 33 vaginal HSILs were diagnosed in 107 females. Females developing vulvar (41.2%) or vaginal (49.5%) lesions also had cervical lesions, whereas 6.5% of females with cervical lesions had vaginal or vulvar lesions. At least 1 of the 14 HPV genotypes was detected in females with vulvar LSIL (72.5%), vulvar HSIL (91.3%), vaginal LSIL (61.9%), and vaginal HSIL (72.7%). Considering only HPV-positive lesions, the nine most common genotypes causing cervical cancer and anogenital warts (6, 11, 16, 18, 31, 33, 45, 52, and 58) were found in 89.4% of vulvar LSILs, 100% of vulvar HSILs, 56.0% of vaginal LSILs, and 78.3% of vaginal HSILs. CONCLUSION: Most vulvar and vaginal lesions were attributable to at least 1 of the 14 HPV genotypes analyzed. Effective immunization programs could potentially prevent substantial numbers of HPV-related vulvar and vaginal LSILs and HSILs.

AB - OBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods. RESULTS: During approximately 4 years of follow-up in 8,798 females, 40 vulvar LSILs and 46 vulvar HSILs were diagnosed in 68 females, and 118 vaginal LSILs and 33 vaginal HSILs were diagnosed in 107 females. Females developing vulvar (41.2%) or vaginal (49.5%) lesions also had cervical lesions, whereas 6.5% of females with cervical lesions had vaginal or vulvar lesions. At least 1 of the 14 HPV genotypes was detected in females with vulvar LSIL (72.5%), vulvar HSIL (91.3%), vaginal LSIL (61.9%), and vaginal HSIL (72.7%). Considering only HPV-positive lesions, the nine most common genotypes causing cervical cancer and anogenital warts (6, 11, 16, 18, 31, 33, 45, 52, and 58) were found in 89.4% of vulvar LSILs, 100% of vulvar HSILs, 56.0% of vaginal LSILs, and 78.3% of vaginal HSILs. CONCLUSION: Most vulvar and vaginal lesions were attributable to at least 1 of the 14 HPV genotypes analyzed. Effective immunization programs could potentially prevent substantial numbers of HPV-related vulvar and vaginal LSILs and HSILs.

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